Efficiency of autofibroblasts in surgical treatment of parodontitis
- Authors: Grudyanov A.I1, Zorin V.L2, Pereverzev R.V1, Zorina A.I2, Bozo I.Y2,3
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Affiliations:
- Central Research Institute of Dentistry and maxillofacial surgery of MH Russia
- Human Stem Cells Institute
- A.I. Evdokimov Moscow State University of Medicine and Dentistry
- Issue: Vol 8, No 3 (2013)
- Pages: 72-77
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/120544
- DOI: https://doi.org/10.23868/gc120544
- ID: 120544
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Abstract
The destructive forms of periodontal disease have a high prevalence. Our study was aimed to evaluate the effectiveness of tissue-engineering osteoplastic material in treatment of patients with periodontal pathology. We have obtained autologous gingival fibroblasts of patients, combined with the hydroxyapatite carriage and transplanted on a standard surgical treatment of periodontitis destructive forms. As a control we used the material without cells implanted into periodontal defects of other affected teeth of the same patients. We have shown the better effect of tissue-engineering osteoplastic material regarding the periodontal pockets depth, but significant difference in bone regeneration and other indicators has not been revealed. Thus, a continuation of researches is required to modify the technology of tissueengineering osteoplastic material creation and to choice the more optimal carrier for gingival fibroblasts.
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About the authors
A. I Grudyanov
Central Research Institute of Dentistry and maxillofacial surgery of MH RussiaMoscow
V. L Zorin
Human Stem Cells InstituteMoscow
R. V Pereverzev
Central Research Institute of Dentistry and maxillofacial surgery of MH RussiaMoscow
A. I Zorina
Human Stem Cells InstituteMoscow
I. Y Bozo
Human Stem Cells Institute; A.I. Evdokimov Moscow State University of Medicine and DentistryMoscow
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