Efficiency of autofibroblasts in surgical treatment of parodontitis
- Authors: Grudyanov A.I1, Zorin V.L2, Pereverzev R.V1, Zorina A.I2, Bozo I.Y2,3
-
Affiliations:
- Central Research Institute of Dentistry and maxillofacial surgery of MH Russia
- Human Stem Cells Institute
- A.I. Evdokimov Moscow State University of Medicine and Dentistry
- Issue: Vol 8, No 3 (2013)
- Pages: 72-77
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/120544
- DOI: https://doi.org/10.23868/gc120544
- ID: 120544
Cite item
Abstract
The destructive forms of periodontal disease have a high prevalence. Our study was aimed to evaluate the effectiveness of tissue-engineering osteoplastic material in treatment of patients with periodontal pathology. We have obtained autologous gingival fibroblasts of patients, combined with the hydroxyapatite carriage and transplanted on a standard surgical treatment of periodontitis destructive forms. As a control we used the material without cells implanted into periodontal defects of other affected teeth of the same patients. We have shown the better effect of tissue-engineering osteoplastic material regarding the periodontal pockets depth, but significant difference in bone regeneration and other indicators has not been revealed. Thus, a continuation of researches is required to modify the technology of tissueengineering osteoplastic material creation and to choice the more optimal carrier for gingival fibroblasts.
Full Text
About the authors
A. I Grudyanov
Central Research Institute of Dentistry and maxillofacial surgery of MH RussiaMoscow
V. L Zorin
Human Stem Cells InstituteMoscow
R. V Pereverzev
Central Research Institute of Dentistry and maxillofacial surgery of MH RussiaMoscow
A. I Zorina
Human Stem Cells InstituteMoscow
I. Y Bozo
Human Stem Cells Institute; A.I. Evdokimov Moscow State University of Medicine and DentistryMoscow
References
- Безрукова И.В. Быстропрогрессирующий пародонтит. М.: Медицинская книга; 2004.
- Григорьян А.С., Грудянов А.И., Фролова О.А. и др. Видовой состав анаэробной микрофлоры пародонтального кармана в зависимости от стадии пародонтита. Стоматология 2009; 4: 43-7.
- Грудянов А.И. Заболевания пародонта. М.: Медицинское информационное агентство; 2009.
- Petersen P.E., Ogawa H. Strengthening the prevention of periodontal disease: the WHO approach. Periodontol 2005; 76: 2187-93.
- Григорьян А.С., Грудянов А.И., Рабухина Н.А. Болезни паро-донта: патогенез, диагностика, лечение. М.: Медицинское информационное агентство; 2004.
- Bowers G.M., Chadroff B., Carnevale R. et al. Histologic evaluation of new attachment apparatus formation in humans. Part III. Periodontol. 1989; 60(12): 683-93.
- Cortellini P, Bowers G. Periodontal regeneration of intrabony defects: An evidence based treatment approach. Int. J. Periodontol. Rest. Dent. 1995; 15:128-45.
- Гололобов В.Г., Дулаев А.К., Деев Р.В. и д.р. Морфофункциональная организация, реактивность и регенерация костной ткани. СПб: 2006; 47 с.
- Зорин В.Л., Зорина А.И., Воложин Г.А. и др. Изучение фенотипического профиля и остеогенных свойств фибробластов десны. Саратовский научно-медицинский журнал 2013; 9(3): 393-7.
- Lorenz K., Sicker M., Schmelzer E. et al. Multilineage differentiation potential of human dermal skin-derived fibroblasts. Exp. Dermatol. 2008; 17(11): 925-32
- Mostafa N.Z., Uludag H., Varkey M. et al. In vitro osteogenic induction of human gingival fibroblasts for bone regeneration. Open Dent J. 2011;5:139-45.
- Huang G.T., Gronthos S., Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J. Dent. Res. 2009; 88(9): 792806.
- Guo W., Chen L., Gong K. et al. Heterogeneous dental follicle cells and the regeneration of complex periodontal tissues. Tissue Eng. Part A. 2012; 18(5-6): 459-70.