Liver pathomorphology of Mus musculus C57BL6 on atherogenic diet
- Authors: Gaifullina RF1, Katina MN1, Abdulhakov SR2, Kasimova LR1, Abdulhakova AR2, Rizvanov AA1
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Affiliations:
- Kazan Federal Volga Region University, Kazan
- Kazan State Medical University, Kazan
- Issue: Vol 7, No 3 (2012)
- Pages: 37-40
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121574
- DOI: https://doi.org/10.23868/gc121574
- ID: 121574
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Abstract
and death worldwide. Liver plays a huge role in pathogenesis
of atherogenic dislipidemia, development and progression of
atherosclerotic lesions. We studied the effect of atherogenic
diet on liver morphology in animal model of diet-induced
atherosclerosis in mice Mus musculus C57BI6. This strain
has a natural ability to develop atherosclerosis, while some
other mouse stains has not. After 14 weeks on atherogenic
diet a severe hepathomegaly (9% of body mass) and lobular
structure deformation was found. We also observed signs of
micro- and macrovesicular steatosis, cell apoptosis, fibrosis
and inflammatory leukocyte infiltration. So, liver not only plays
an important role in dislipidemia, but it is also a target-organ
in lipid metabolism imbalance.
Keywords
About the authors
R F Gaifullina
Kazan Federal Volga Region University, KazanKazan Federal Volga Region University, Kazan
M N Katina
Kazan Federal Volga Region University, KazanKazan Federal Volga Region University, Kazan
S R Abdulhakov
Kazan State Medical University, KazanKazan State Medical University, Kazan
L R Kasimova
Kazan Federal Volga Region University, KazanKazan Federal Volga Region University, Kazan
A R Abdulhakova
Kazan State Medical University, KazanKazan State Medical University, Kazan
A A Rizvanov
Kazan Federal Volga Region University, KazanKazan Federal Volga Region University, Kazan
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