Liver pathomorphology of Mus musculus C57BL6 on atherogenic diet
- Авторлар: Gaifullina RF1, Katina MN1, Abdulhakov SR2, Kasimova LR1, Abdulhakova AR2, Rizvanov AA1
-
Мекемелер:
- Kazan Federal Volga Region University, Kazan
- Kazan State Medical University, Kazan
- Шығарылым: Том 7, № 3 (2012)
- Беттер: 37-40
- Бөлім: Articles
- ##submission.dateSubmitted##: 11.01.2023
- ##submission.datePublished##: 15.09.2012
- URL: https://genescells.ru/2313-1829/article/view/121574
- DOI: https://doi.org/10.23868/gc121574
- ID: 121574
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Рұқсат ақылы немесе тек жазылушылар үшін
Аннотация
and death worldwide. Liver plays a huge role in pathogenesis
of atherogenic dislipidemia, development and progression of
atherosclerotic lesions. We studied the effect of atherogenic
diet on liver morphology in animal model of diet-induced
atherosclerosis in mice Mus musculus C57BI6. This strain
has a natural ability to develop atherosclerosis, while some
other mouse stains has not. After 14 weeks on atherogenic
diet a severe hepathomegaly (9% of body mass) and lobular
structure deformation was found. We also observed signs of
micro- and macrovesicular steatosis, cell apoptosis, fibrosis
and inflammatory leukocyte infiltration. So, liver not only plays
an important role in dislipidemia, but it is also a target-organ
in lipid metabolism imbalance.
Негізгі сөздер
Авторлар туралы
R Gaifullina
Kazan Federal Volga Region University, KazanKazan Federal Volga Region University, Kazan
M Katina
Kazan Federal Volga Region University, KazanKazan Federal Volga Region University, Kazan
S Abdulhakov
Kazan State Medical University, KazanKazan State Medical University, Kazan
L Kasimova
Kazan Federal Volga Region University, KazanKazan Federal Volga Region University, Kazan
A Abdulhakova
Kazan State Medical University, KazanKazan State Medical University, Kazan
A Rizvanov
Kazan Federal Volga Region University, KazanKazan Federal Volga Region University, Kazan
Әдебиет тізімі
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