Liver pathomorphology of Mus musculus C57BL6 on atherogenic diet
- 作者: Gaifullina RF1, Katina MN1, Abdulhakov SR2, Kasimova LR1, Abdulhakova AR2, Rizvanov AA1
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隶属关系:
- Kazan Federal Volga Region University, Kazan
- Kazan State Medical University, Kazan
- 期: 卷 7, 编号 3 (2012)
- 页面: 37-40
- 栏目: Articles
- ##submission.dateSubmitted##: 11.01.2023
- ##submission.datePublished##: 15.09.2012
- URL: https://genescells.ru/2313-1829/article/view/121574
- DOI: https://doi.org/10.23868/gc121574
- ID: 121574
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详细
and death worldwide. Liver plays a huge role in pathogenesis
of atherogenic dislipidemia, development and progression of
atherosclerotic lesions. We studied the effect of atherogenic
diet on liver morphology in animal model of diet-induced
atherosclerosis in mice Mus musculus C57BI6. This strain
has a natural ability to develop atherosclerosis, while some
other mouse stains has not. After 14 weeks on atherogenic
diet a severe hepathomegaly (9% of body mass) and lobular
structure deformation was found. We also observed signs of
micro- and macrovesicular steatosis, cell apoptosis, fibrosis
and inflammatory leukocyte infiltration. So, liver not only plays
an important role in dislipidemia, but it is also a target-organ
in lipid metabolism imbalance.
作者简介
R Gaifullina
Kazan Federal Volga Region University, KazanKazan Federal Volga Region University, Kazan
M Katina
Kazan Federal Volga Region University, KazanKazan Federal Volga Region University, Kazan
S Abdulhakov
Kazan State Medical University, KazanKazan State Medical University, Kazan
L Kasimova
Kazan Federal Volga Region University, KazanKazan Federal Volga Region University, Kazan
A Abdulhakova
Kazan State Medical University, KazanKazan State Medical University, Kazan
A Rizvanov
Kazan Federal Volga Region University, KazanKazan Federal Volga Region University, Kazan
参考
- Fuster V. Epidemic of cardiovascular disease and stroke: the three main challenges. Presented at the 71st scientific sessions of the American Heart Association. Dallas, Texas. Circulation 1999; 99(9): 1132-7.
- Drew A.F., editor. Atherosclerosis: Experimental methods and protocols. Methods in Molecular Medicine. Humana Press; 2001.
- Spiteller G. Is atherosclerosis a multifactorial disease or is it induced by a sequence of lipid peroxidation reactions? Ann. NY Acad. Sci. 2005; 1043: 355-66.
- Russell J.C., Proctor S.D. Small animal models of cardiovascular disease: tools for the study of the roles of metabolic syndrome, dyslipidemia, and atherosclerosis. Cardiovasc. Pathol. 2006. 15(6): 318-30.
- Schreyer S.A., Wilson D.L., LeBoeuf R.C. C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis. Atherosclerosis 1998; 136(1): 17-24.
- Буеверова Е.Л., Ивашкин В.Т. Атерогенная дислипиде- мия и печень. Российские медицинские вести 2008; 13(1): 17-23.
- Генин А.М., Капланский А.С. Биоэтические правила прове- дения исследований на человеке и животных в авиационной, кос- мической и морской медицине. Авиакосмическая и экологическая медицина 2001; 4: 14-20.
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