The influence of P2-receptors on the cytotoxic effect of cisplatine in squamous cell uterine cervix cancer in vitro
- 作者: Raginov I.S1,2, Muhamedyarova G.K1, Panov A.V1
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隶属关系:
- Kazan State Medicale University
- Kazan (Volga region) Federal University
- 期: 卷 9, 编号 3 (2014)
- 页面: 240-241
- 栏目: Articles
- ##submission.dateSubmitted##: 05.01.2023
- ##submission.datePublished##: 15.12.2014
- URL: https://genescells.ru/2313-1829/article/view/120330
- DOI: https://doi.org/10.23868/gc120330
- ID: 120330
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详细
To investigate the influence of purinergic signalling in squamous cell uterine cervix cancer in vitro, the effect of combining ATP (nonselective agonist P2-receptor) with the nonselective P2 receptor antagonists PPADS (P2X-receptors), RB2 (P2Y-receptors) and suramin (both P2Y-receptors and P2X-receptors) and the chemotherapeutic drug cisplatin was assessed. ATP effectively reduces up to twofold the growth of uterine cervix cancer cells. RB2 promoted survival of tumor cell by 52,1% compared to the control. Combinations of the cisplatin + ATP demonstrated a strong sensitivity at 2,7 fold. However, this effect of ATP was reversed in the presence of RB2 by 41%. This highlights the potential use of selective P2Y receptor agonists in the treatment of squamous cell uterine cervix cancer.
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作者简介
I. Raginov
Kazan State Medicale University; Kazan (Volga region) Federal University
G. Muhamedyarova
Kazan State Medicale University
A. Panov
Kazan State Medicale University
参考
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