The influence of P2-receptors on the cytotoxic effect of cisplatine in squamous cell uterine cervix cancer in vitro
- Авторлар: Raginov I.S1,2, Muhamedyarova G.K1, Panov A.V1
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Мекемелер:
- Kazan State Medicale University
- Kazan (Volga region) Federal University
- Шығарылым: Том 9, № 3 (2014)
- Беттер: 240-241
- Бөлім: Articles
- ##submission.dateSubmitted##: 05.01.2023
- ##submission.datePublished##: 15.12.2014
- URL: https://genescells.ru/2313-1829/article/view/120330
- DOI: https://doi.org/10.23868/gc120330
- ID: 120330
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
To investigate the influence of purinergic signalling in squamous cell uterine cervix cancer in vitro, the effect of combining ATP (nonselective agonist P2-receptor) with the nonselective P2 receptor antagonists PPADS (P2X-receptors), RB2 (P2Y-receptors) and suramin (both P2Y-receptors and P2X-receptors) and the chemotherapeutic drug cisplatin was assessed. ATP effectively reduces up to twofold the growth of uterine cervix cancer cells. RB2 promoted survival of tumor cell by 52,1% compared to the control. Combinations of the cisplatin + ATP demonstrated a strong sensitivity at 2,7 fold. However, this effect of ATP was reversed in the presence of RB2 by 41%. This highlights the potential use of selective P2Y receptor agonists in the treatment of squamous cell uterine cervix cancer.
Негізгі сөздер
Толық мәтін
Авторлар туралы
I. Raginov
Kazan State Medicale University; Kazan (Volga region) Federal University
G. Muhamedyarova
Kazan State Medicale University
A. Panov
Kazan State Medicale University
Әдебиет тізімі
- Idzko M., Ferrari D., Eltzschig H. Nucleotide signalling during inflammation. Nature 2014; 509: 310-5.
- Мингалеева Р.Н., Соловьева В.В., Блатт Н.Л. и др. Применение культур клеток и тканей для скрининга противоопухолевых препаратов in vitro // Клеточная трансплантология и тканевая инженерия 2013; 8(2): 20-8.
- Shabbir M., Ryten M., Thompson C. et al. Characterization of calcium-independent purinergic receptor-mediated apoptosis in hormone-refractory prostate cancer. BJU Int. 2008; 101(3): 352-9.
- White N., Knight G., Butler P. et al. An in vivo model of melanoma: treatment with ATP. Purinergic Signal 2009; 5(3): 32733.
- Ryu J., Jantaratnotai N., Serrano-Perez M. et al. Block of purinergic P2X7R inhibits tumor growth in a C6 glioma brain tumor animal model. J Neuropathol Exp. Neurol. 2011; 70(1): 13-22.
- Li X., Qi X., Zhou L. et al. P2X(7) receptor expression is decreased in epithelial cancer cells of ectodermal, uro-genital sinus, and distal paramesonephric duct origin. Purinergic Signal 2009; 5(3): 351-68.
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