The effect of mesenchymal stromal cells and the mobilization of stem cells in bone marrow on the development of nephrosclerosis



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Abstract

The effects of autologous mesenchymal stromal cell CMSC) transplantation and of bone marrow IBM) hematopoietic cells mobilization on the course of rhabdomyolysis-induced nephropathy in mice were studied. Both MSC transplantation and mobilization of hematopoietic BM cells were demonstrated to improve function and to inhibit fibrotic transformation of the kidney. At the same time MSC transplantation had no impact on the levels of mononuclear infiltration and on the casts formation, but decreased systemic proinflammatory responsiveness. Mobilization of BM hematopoietic cells, on the contrary, enhanced the levels of mononuclear infiltration and casts formation in renal tissue, but did not alter the systemic proinflammatory responsiveness. Both MSC transplantation and BM hematopoietic cells mobilization were concluded to be the most promising approaches to the development of novel therapeutic methods to treat progressive nephropathy.

About the authors

S N Belogorodtsev

Ya Sh Shvarts

P N Filimonov

G V Seledtsova

S N Belogorodtsev

State Research Institute of Clinical Immunology Siberian Branch of RAMS, Novosibirsk

State Research Institute of Clinical Immunology Siberian Branch of RAMS, Novosibirsk

Ya S Schvarz

State Scientific-Research Institute of Therapy Siberian Branch of RAMS, Novosibirsk

State Scientific-Research Institute of Therapy Siberian Branch of RAMS, Novosibirsk

P N Filimonov

Novosibirsk Research Institute of Tuberculosis, Novosibirsk

Novosibirsk Research Institute of Tuberculosis, Novosibirsk

G V Seledtsova

State Research Institute of Clinical Immunology Siberian Branch of RAMS, Novosibirsk

State Research Institute of Clinical Immunology Siberian Branch of RAMS, Novosibirsk

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