Transplanted fetal cells are involved in the pathological process in Parkinson's disease


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作者简介

I. Bozo

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Email: bozo.ilya@gmail.com

参考

  1. Jankovic J. Parkinson’s disease: clinical features and diagnosis. J. Neurol. Neurosurg. Psychiatr. 2008; 79(4): 368—76.
  2. Lepoutre A., Devos D., Blanchard-Dauphin A. A specific clinical pattern of camptocormia in Parkinson’s disease. J. Neurol. Neurosurg. Psychiatr. 2006; 77(11): 1229-34.
  3. Jenner P. Oxidative mechanisms in nigral cell death in Parkinson’s disease. Mov. Disord. 1998; 13(1): 24—34.
  4. Cotzias G. Manganese, melanins and the extrapyramidal system. J. Neurosurg. 1966; 24 (1): 170-80.
  5. Lang A.E., Obeso J.A. Challenges in Parkinson’s disease: restoration of the nigrostriatal dopamine system is not enough. Lancet Neurol. 2004; 3(5): 309-16.
  6. Wernig M., Zhao J., Pruszak J. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson’s disease. PNAS 2008; 105(15): 5856—61.
  7. Freed C.R., Greene P.E., Breeze R.E. et al. Transplantation of embryonic dopamine neurons for severe Parkinson’s disease. N. Engl. J. Med. 2001; 344: 710-19.
  8. Bjцrklund A., Dunnett S.B., Brundin P. et al. Neural transplantation for the treatment of Parkinson’s disease. Lancet Neurol. 2003; 2(7): 437-15.
  9. Olanow C.W., Perl D.P., DeMartino G.N. et al. Lewy-body formation is an aggresome-related process: a hypothesis. Lancet Neurol. 2004; 3(8): 496-503.
  10. Duffy P., Tennyson V. Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus coeruleus in Parkinson’s disease. J. Neuropathol. Exp. Neurol. 1965; 24: 398-414
  11. Li J.-Y., Englund E., Holton J.L. et al. Lewy bodies in grafted neurons in subjects with Parkinson’s disease suggest host-to-graft disease propagation. Nat. Med. 2008; 14(5): 501—3.
  12. Kordower J.H., Chu Y., Hauser R.A. et al. Lewy body—like pathology in long-term embryonic nigral transplants in Parkinson’s disease. Nat. Med. 2008; 14(5): 504-6.
  13. Mendez I., Vicuela A., Astradsson A. et al. Dopamine neurons implanted into people with Parkinson’s disease survive without pathology for 14 years. Nat. Med. 2008; 14(5): 507-9.

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2. Probable mechanisms underlying the spread of pathological changes to transplanted neurons in Parkinson's disease. According to R. Brundin et al. [2008] with changes

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