Reprogramming of pancreatic exocrinocytes into functionally active β-cells


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作者简介

P. Belousov

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Email: bozo.ilya@gmail.com

参考

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  4. Baeyens L., De Breuck S., Lardon J. et al. In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia 2005; 48(1): 49-57.
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  10. Wang A. Y., Ehrhardt A., Xu H. et al. Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver. Mol. Ther. 2007; 15(2): 255-63.
  11. Ferber S., Halkin A., Cohen H. et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nature Med. 2000; 6(5): 568-72.
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  14. Baeyens L., De Breuck S., Lardon J. et al. In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia 2005; 48(1): 49-57.
  15. Minami K., Okuno M., Miyawaki K. et al. Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. PNAS 2005; 102(42): 15116-21.
  16. Minami K., Seino S. Pancreatic acinar-to-beta cell transdifferentiation in vitro. Front. Biosci. 2008; 13: 5824—37.
  17. Okuno M., Minami K., Okumachi A. et al. Generation of insulin- secreting cells from pancreatic acinar cells of animal models of type 1 diabetes. Am. J. Physiol. Endocrinol. Metab. 2007; 292(1): E158—E165.
  18. Sapir T., Shternhall K., Meivar-Levy I. et al. Cell-replacement therapy for diabetes: generating functional insulin-producing tissue from adult human liver cells. PNAS 2005; 102: 7964-9.
  19. Heremans Y., Van De Casteele M., in’t Veld P. et al. Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J. Cell Biol. 2002; 159(2): 303—12.
  20. Gasa R., Mrejen C., Leachman N. et al. Proendocrine genes coordinate the pancreatic islet differentiation program in vitro. PNAS 2004; 101(36): 13245-50.

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