Eosinophilia: approaches to differential diagnosis of reactive and clonal eosinophilia

The features of changes in blood and bone marrow of patients with reactive (1 group, n = 8) and clonal (2 group, n = 13)eosinophilia. Revealed correlations between cellular elements, depending on the etiology, a statistically significant difference between the two independent groups of patients in terms of cellular composition of the blood and bone marrow. A common feature of both groups was high blood eosinophil counts and eosinophilic hyperplasia of the bone marrow. The absence of the correlation of some indicators of peripheral blood and hematopoietic progenitors in the bone marrow in patients 1 and 2 groups. Compared with patients with reactive eosinophilias number of correlations between indicators of hemogram and myelogram in patients with klonal eosinophilias were significantly less. Identified weak false-positive relationship between the number of neutrophils in the blood and bone marrow's neutrophils with monoclonal eosinophilias. Correlation of eosinophils and basophils blood in patients with klonal eosinophilias has been declared negative (p>0.05). On the contrary, there was a clear correlation between the two groups of red blood cells and eosinophils and their precursors. It is suggested the possible disregulatory process occurring under the action of the cytokine environment hematopoietic cells in hematologic malignancies.

differential diagnosis, clonal and reactive eosinophiliae, hypereosinophilic syndrome