Adipose-derived stromal vascular fraction as an alternative source of cells for the regenerative medicine

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Abstract

The adipose tissue is considered as the most convenient and abundant source of cells for the regenerative medicine. The number of progenitor cells in the adipose tissue significantly exceeds their amount in the bone marrow and other tissues. Therefore, adipose-derived stromal vascular fraction comprising distinct populations of stem and progenitor cells can be relatively easily isolated from lipoaspirates and may then be used in various pathological conditions. However, the profile of this cell fraction with a significant therapeutic potential remains unclear, and there are no standardized protocols for its isolation and evaluation. in this article, we reviewed the data on the potential use of adipose-derived stromal vascular fraction in the regenerative medicine. We described the main historical milestones and performed a comprehensive analysis of the sources of adipose-derived stromal vascular fraction, techniques of its isolation, features, immunophenotype and differentiation pathways

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About the authors

Ä. V Veremeev

“JoinTechCeir LLC

Email: al.veremeev@gmail.com

R. N Bolgarin

“JoinTechCeir LLC

M. A Petkova

“JoinTechCeir LLC

N. Katz

“JoinTechCeir LLC

V. G Nesterenko

N.F. Gamaleya Federal Research Institute of Epidemiology and Microbiology

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