Нейро-иммунные взаимодействия в холинергическом противовоспалительном пути



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Аннотация

Все больше исследований свидетельствуют о том, что нервная и иммунная системы активно взаимодействуют между собой. Изучение механизмов, лежащих в основе развития септического шока, привело к открытию качественно нового типа нейро-иммунных взаимодействий - холинергического противовоспалительного пути с участием блуждающего нерва. Однако несмотря на то, что электрическая стимуляция блуждающего нерва уже активно применяется для снятия симптомов некоторых аутоиммунных заболеваний, многие молекулярные и клеточные аспекты холинергического противовоспалительного пути остаются неизвестными или спорными. В настоящем обзоре рассматриваются механизмы рецепции медиаторов воспаления афферентными окончаниями блуждающего нерва и клетками нервной ткани в области area postrema, нервные центры, предположительно участвующие в обработке иммунной информации, эфферентные парасимпатические эффекты на иммунную систему, в частности выделение провоспалительных цитокинов макрофагами селезенки, а также роль холинергического противовоспалительного пути в поддержании гомеостаза в организме.

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О. П Тучина

Институт живых систем Балтийского федерального университета им. И. Канта

Email: otuchina@kantiana.ru
Калининград, Россия

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