Clinical and experimental study on the use of combined cell transplant on the basis of multipotent mesenchymalstromal cells of adipose tissue in patients with severe deficiency of jaws bone tissue

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The clinical and experimental study on the restoration of
bone tissue with tissue engineering scaffold based on stem
cells of adipose tissue and resorbable osteoplastic matrix. In a
pilot study proved the effectiveness of the transplant, founded
the dates of dental implantation. Use of tissue engineering
scaffold led to organotypic reconstruction of bone tissue in
the field of transplantation in patients with severe atrophy of
the alveolar process of the maxilla and mandible. As part of a
clinical trial were treated 20 patients.

About the authors

I S Alexeeva

Central Research Institute of Dental and Maxillofacial Surgery, Moscow

Central Research Institute of Dental and Maxillofacial Surgery, Moscow

A V Volkov

Central Research Institute of Dental and Maxillofacial Surgery, Moscow

Central Research Institute of Dental and Maxillofacial Surgery, Moscow

A A Kulakov

Central Research Institute of Dental and Maxillofacial Surgery, Moscow

Central Research Institute of Dental and Maxillofacial Surgery, Moscow

D V Goldshtein

CJSC «ReMeTeks», MoscowMedical Genetics Research Center RAMS, Moscow

CJSC «ReMeTeks», MoscowMedical Genetics Research Center RAMS, Moscow

References

  1. Caplan A.I. Mesenchymal stem cells. Orthop. Res. 1991; 9(5): 641-50.
  2. Ashman A. Postextraction ridge preservation using a synthetic alloplast. Gen. Dent. 2000; 48(3): 304-12.
  3. Ashman А. Ridge preservation: important buzzwords in dentistry. Oral Implantol. 2000; 26(4): 276-90.
  4. Atwood D.A. Reduction of residual ridges: а major oral disease entity. Prosthet. Dent. 1971; 26: 266-79.
  5. Sheller E.L., Krebsbach P.H., Kohn D.H. Tissue engineering: state of the art in oral rehabilitation. Oral Rehabil. 2009; 36(5): 368-89.
  6. Athanasiou K.A., Zhu C., Lanctot D.R. et al. Fundamentals of biomechanics in tissue engineering of bone. Tissue Eng. 2000. 6: 361-81.
  7. Деев Р.В. Постравматическая регенерация костной ткани при трансплантации костномозговых стромальных клеток [диссерта- ция]. Санкт-Питербург: Военно-медицинская академия; 2006.
  8. Иванов С.Ю., Кузнецов Р.К., Чайлахян Р.К. и др. Перспек- тивы применения в стоматологии материалов «Биоматрикс» и «Алломатрикс-имплант» в сочетании с остеогенными клетками- предшественниками костного мозга Клиническая имплантология и стоматология 2000; 3-4: 17-8.
  9. Krebsbach P.H., Kuznetsov S.A., Bianco P. et al. Bone marrow stromal cells: characterization and clinical application. Crit. Rev. Oral. Biol. Med. 1999; 10(2): 165-81.
  10. Kwan M.D., Slater B.J., Wan D.C. et al. Cell-based therapies for skeletal regenerative medicine. Hum. Mol. Genet. 2008; 17: R93-8.
  11. Muscler G.F, Nacamoto C., Griffith L.G. Engeneering principles of clinical cell-based tissue engeneering. Bone Joint Surg. Am. 2004; 86-A(7): 1541-58.
  12. Rose F.R., Oreffo R.O. Bone tissue engineering: hope vs hype. Biochem. Biophys. Res. Commun. 2002; 292: 1-7.
  13. Charbord P. Bone marrow mesenchymal stem cells: historical overview and concepts. Human Gene Therapy 2010: 1045-56.
  14. Bianco P., Robey P.G. Stem cells in tissue engineering. Nature 2001; 414(6859): 118-21
  15. Gimble J.M., Nuttall M.E. Bone and fat: old questions, new insights. Endocrine 2004; 23: 183-8.
  16. Gimble J.M., Katz A.J., Bunnell B.A. Adipose-derived stem cells for regenerative medicine. Circ. Res. 2007; 100: 1249-60.
  17. Gimble J.M, Grayson W., Guilak F. et al. Adipose tissue as a stem cell source for musculoskeletal regeneration. Front. Biosci. (Schol Ed). 2011; 3: 69-81.
  18. Mizuno H. Adipose-derived stem cells for tissue repair and regeneration: ten years of research and a literature review. Nippon. Med. Sch. 2009; 76(2): 56-66.
  19. Mizuno H. Adipose-derived stem and stromal cells for cellbased therapy: current status of preclinical studies and clinical trials. Curr. Opin. Mol. Ther. 2010; 12(4): 442-9.
  20. Mosna F., Sensebé L., Krampera M. Human bone marrow and adipose tissue mesenchymal stem cells: a user's guide. Stem Cells Develop. 2010; 19(10): 1449-70.
  21. Бухарова Т.Б., Арутюнян И.В., Шустров С.А. и др. Тканеин- женерная конструкция на основе мультипотетных стромальных кле- ток жировой ткани и материала «Остеоматрикс» для регенерации костной ткани. Клет. Тех. Биол. Мед. 2011; 3: 167-73.
  22. Волков А.В, Алексеева И.С., Бухарова Т.Б. и др. Создание ин- дивидуальных трехмерных конструкций для восстановления челюстно- лицевых костных дефектов. Пародонтология 2011; 4: 61-4.
  23. Волков А.В, Алексеева И.С., Кулаков А.А. и др. Регенерация костей черепа взрослых кроликов при имплантации коммерческих остеоиндуктивных материалов и трансплантации тканеинженерной конструкции. Клет. Тех. Биол. Мед. 2010; 2: 72-7.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2012 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: 

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies