New data on spontaneous oncogenetic transformation of "adult" human bone marrow stem cells in vitro

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About the authors

A. V. Bersenev

Author for correspondence.
Email: redaktor@celltranspl.ru
Russian Federation

References

  1. Таі М.-H., Chang C.-С., Olson L.K., Trosko J.E. 0ct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. Carcinogenesis doi:1O.1O93/carcin/bgh321.
  2. Singh S.K., Hawkins C., Clarke I.D. et al. Identification of human brain tumour initiating cells. Nature 2004; 432: 396-401.
  3. Rubio D„ Garcia-Castro J., Martin M.C. et al. Spontaneous human adult stem cell transformation. Cancer Res. 2005; 65: 3035-9.
  4. Kassem M„ Burns J.S., Garcia C.J., Rubio M.D. Adult stem cells and cancer. Cancer Res. 2005; 65: 9601.
  5. Serakinci N.. Guldberg P„ Burns J.S. et al. Adult human mesenchymal stem cell as a target for neoplastic transformation. Oncogene 2004; 23; 29: 5095-8.
  6. Stenderup K., Justesen J., Clausen C., Kassem M. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone 2003; 33: 919-26.
  7. Toren A., Bielorai B., Jacob-Hirsch J. et al. CD133-positive hematopoietic stem cell «sternness» genes contain many genes mutated or abnormally expressed in leukemia. Stem Cells 2005; 23[8):1142-53.
  8. Miura M„ Miura Y., Padilla-Nash H.M. et al. Accumulated chromosomal instability in murine bone marrow mesenchymal stemcells leads to malignant transformation. Stem Cells 2005; Epub.

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