Clinical significance of the fetal microchimerism for mother

Capa
  • Autores: Rumyantsev AG1, Kurcer MA2, Mareeva J.M3, Misjurin AV3, Roumiantsev SA4, Ustjugov AJ.3
  • Afiliações:
    1. 1 D. Rogachev Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunologyof the Ministry of Health and Social Development of the Russia, Moscow2 N.I. Pirogov Russian National Research Medical University of the Ministry of Healthand Social Development of the Russia, Moscow
    2. N.I. Pirogov Russian National Research Medical University of the Ministry of Healthand Social Development of the Russia, Moscow
    3. D. Rogachev Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunologyof the Ministry of Health and Social Development of the Russia, Moscow
    4. D. Rogachev Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunologyof the Ministry of Health and Social Development of the Russia, Moscow2 N.I. Pirogov Russian National Research Medical University of the Ministry of Healthand Social Development of the Russia, Moscow
  • Edição: Volume 7, Nº 2 (2012)
  • Páginas: 103-111
  • Seção: Articles
  • ##submission.dateSubmitted##: 11.01.2023
  • ##submission.datePublished##: 15.06.2012
  • URL: https://genescells.ru/2313-1829/article/view/121647
  • DOI: https://doi.org/10.23868/gc121647
  • ID: 121647


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Resumo

Fetal cells enter into mother`s body during pregnancy
and remain there for many years. In female body accumulate
genetically foreign cells of all pregnancies, regardless of what
they have ended (a miscarriage, an abortion or a childbirth). It
is shown that fetal cells are found in various maternal tissues
and organs including blood, bone marrow, liver, lungs and skin.
The interaction nature of foreign cells entering the mothers
body in a natural way with her own cells and immune system
of mother can be extrapolated to the study of chimerism in
the iatrogenic effects on the body, such as hematopoietic
stem cell transplantation or blood transfusion. Natural fetomaternal
microchimerism has important effect on the immune
status of women contributing to development of autoimmune
conditions and tolerance to transplants. Understanding
the fact that fetal cells able to pass through the placental
and blood brain barrier, to migrate in various tissues
and to differentiate in multiple cell types can be used for
development of cell therapy. The studies of long-term effects
feto- maternal microchimerism can get more favorable and
unfavorable prognostic criteria for womens health, but also
able to fundamentally change the understanding of current
principles of clinical genetics.
This paper presents an overview of knowledge about
microchimerism appeared during pregnancy and current views
on the implications of this unique biological phenomenon.

Sobre autores

A Rumyantsev

1 D. Rogachev Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunologyof the Ministry of Health and Social Development of the Russia, Moscow2 N.I. Pirogov Russian National Research Medical University of the Ministry of Healthand Social Development of the Russia, Moscow

1 D. Rogachev Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunologyof the Ministry of Health and Social Development of the Russia, Moscow2 N.I. Pirogov Russian National Research Medical University of the Ministry of Healthand Social Development of the Russia, Moscow

M Kurcer

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthand Social Development of the Russia, Moscow

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthand Social Development of the Russia, Moscow

Ju Mareeva

D. Rogachev Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunologyof the Ministry of Health and Social Development of the Russia, Moscow

D. Rogachev Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunologyof the Ministry of Health and Social Development of the Russia, Moscow

A Misjurin

D. Rogachev Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunologyof the Ministry of Health and Social Development of the Russia, Moscow

D. Rogachev Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunologyof the Ministry of Health and Social Development of the Russia, Moscow

S Roumiantsev

D. Rogachev Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunologyof the Ministry of Health and Social Development of the Russia, Moscow2 N.I. Pirogov Russian National Research Medical University of the Ministry of Healthand Social Development of the Russia, Moscow

D. Rogachev Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunologyof the Ministry of Health and Social Development of the Russia, Moscow2 N.I. Pirogov Russian National Research Medical University of the Ministry of Healthand Social Development of the Russia, Moscow

A Ustjugov

D. Rogachev Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunologyof the Ministry of Health and Social Development of the Russia, Moscow

D. Rogachev Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunologyof the Ministry of Health and Social Development of the Russia, Moscow

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