Implant-Carrier of Cells Made of Porous Permeable Titanium

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The article presents the analysis of properties of a new material for implant production - porous titanium. It is demonstrated that the material possesses adequate mechanical characteristics. The absorption ofbiologic fluid was 7.5%. The material is compatible to living cells. While mouse bone marrow cells and fetal human hepatocytes were being cultured under Dextor system conditions and in vivo in mice such an implant functioned as a source of hemopoesis within the whole period of observation - up to 9 months. The data on depressing influence on growth and development of lymphomas were obtained. Thus, the material given can be considered as a perspective carrier for cells in transplantation and artificial organ creation.

Full Text

Restricted Access

About the authors

V. I. Itin

Structural Macrokynetic Department of Tomsk Scientific Senter (SD PAS)

Author for correspondence.
Email: redaktor@celltranspl.ru
Russian Federation, Tomsk

G. A. Pribytkov

Institute of Physics Durability and Materialresearch

Email: redaktor@celltranspl.ru
Russian Federation, Tomsk

I. A. Khlusov

Institute of Physics Durability and Materialresearch

Email: redaktor@celltranspl.ru
Russian Federation, Tomsk

L. V. Zagrebin

Information-Cellular Medicine Center Lmd

Email: redaktor@celltranspl.ru
Russian Federation, Moscow

S. S. Shestov

Information-Cellular Medicine Center Lmd

Email: redaktor@celltranspl.ru
Russian Federation, Moscow

References

  1. Vacanti J.P., Vacanti C.A., Langer R.S. Neomorphogenesis of cartilage in vivo from cell culture. WO 901 2603; A61F2/30; A61 L27/00; C12N5/ 00. Publication data: 1 990-11 -01. Priority number: US 1 98903391 55 198-904-17.
  2. Vacanti J.P.., Langer R.S., Johnson L., Griffith-Cima L. Method for implanting large volumes of cell on polymeric matrices. WO 9012604; A61L27/ 00 Publication date: 1990-11 -01. Priority number: US 19890343158 198904-25.
  3. Mears D.C. Regeneration of living tissues by growth of isolated cells in porous implant and product thereof. United States Patent 4553272; A61F001/ 00 February 26.1981. November 19, 1985.
  4. Caplan A.J., Haynesworth S.E. Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells. United States Patent 5197985. A61F002/28; A61K035/12 November 16, 1990. March 30, 1993.
  5. Caplan A.J., Haynesworth S.E. Method for treating connective tissue disorder. United States Patent 5226914 A61F002/28; A61K035/12 November 16, 1990. July 13, 1993.
  6. Fournier R.L., Goldblatt P.J., Horner J.M., Sarver J.G. Bioartificial pancreas. United States Patent 5387237 A61F002/02 A61F002/00; A61M037/00; A61M005/32 Jule 21, 1993. February 7, 1995.
  7. Гюнтер В.Э., Дамбаев Г.Ц., Ходоренко В.Н. и др. Носитель клеточных культур искусственных внутренних органов. Патент РФ 2191607; 7A61L27/ 06; A61L27/56 Заявл. 2000.06.23. □публ. 2002.10.27.
  8. Дамбаев Г.Ц., Гюнтер В.Э., Загребин Л.В. и др. Имплантат для хирургического лечения заболеваний внутренних органов. Патент РФ 2143867; 7A61F2/02. заявл. 1997.11.12. □публ.2000.01.10.
  9. Итин В.И., Найбороденко Ю.С. Высокотемпературный синтез интерметаллических соединений. 1989; Томск: 214.
  10. Ziats N., Miller K., Anderson J. In vitro and in vivo interaction of cells with biomaterials. Biomat. 1988; 9: 5-13.
  11. Helsen J.A., Breme H.J. (ed) Metals as biomaterials. 1998; Chichester, John Willey & Sons: 498.
  12. Бойко И.В., Сурков □.А., Кондратов А.А.. Вишневский В.А. Экспериментальное обоснование использования пористого титана в эндопротезировании. □ртоп., травматология и протезирование 1999; 1: 38-41.
  13. Fetsch P., Bingmann D. Nervenzellen in vitro als Bioindikatoren far Gewebevertraglichkeit von Implantatmaterialen. Z. Zahnarztl. Implantol. 1988; 4(4): 266-9.
  14. Березовский В.А., Колотилов H.H. Биофизические характеристики тканей человека. 1990; Киев: Наукова думка: 224.
  15. Буякова С.П., Хлусов И.А., Кульков С.Н. Пористая циркониевая керамика для эндопротезирования костной ткани. Физическая мезомеханика 2004. 7(2): 127-30.

Supplementary files

Supplementary Files
Action
1. JATS XML
2. Fig.1. Morphology of titanium powder particles

Download (126KB)
3. Fig. 2. Morphology of the frame structure of sintered titanium

Download (80KB)
4. Fig. 3. Diagram of uniaxial compression of sintered titanium

Download (38KB)
5. Fig. 4. The number of viable cells on porous titanium under Dexter culture conditions

Download (30KB)
6. Fig. 5. CFU-G, CFU-GM detected in the liquid phase of cell culture on porous titanium

Download (29KB)

Copyright (c) 2006 Eco-Vector



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: 

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies