Some possible molecular mechanisms of VEGF encoding plasmids functioning
- Авторлар: Grigorian, AS1, Schevchenko KG1
-
Мекемелер:
- Human Stem Cells Institute, Moscow
- Шығарылым: Том 6, № 3 (2011)
- Беттер: 24-28
- Бөлім: Articles
- ##submission.dateSubmitted##: 11.01.2023
- ##submission.datePublished##: 15.09.2011
- URL: https://genescells.ru/2313-1829/article/view/121545
- DOI: https://doi.org/10.23868/gc121545
- ID: 121545
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Рұқсат ақылы немесе тек жазылушылар үшін
Аннотация
Gene therapeutic approaches to the restoration of the
ischemic tissue perfusion are considered very promising,
but to this time the molecular mechanisms which allow the
therapeutic gene encoding plasmid to transfect the target
cell and underlie the positive clinical effects remain unknown.
In this review the possible molecular mechanisms of the
angiogenic factor VEGF encoding plasmid penetration into the
cytoplasm and the nucleus of the target cell are discussed,
and also the methods for better transfection and the gene of
interest expression are proposed.
ischemic tissue perfusion are considered very promising,
but to this time the molecular mechanisms which allow the
therapeutic gene encoding plasmid to transfect the target
cell and underlie the positive clinical effects remain unknown.
In this review the possible molecular mechanisms of the
angiogenic factor VEGF encoding plasmid penetration into the
cytoplasm and the nucleus of the target cell are discussed,
and also the methods for better transfection and the gene of
interest expression are proposed.
Авторлар туралы
A Grigorian,
Human Stem Cells Institute, MoscowHuman Stem Cells Institute, Moscow
K Schevchenko
Human Stem Cells Institute, MoscowHuman Stem Cells Institute, Moscow
Әдебиет тізімі
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