Effect of G-CSF on proangiogenic properties mobilized peripheral blood cells in patients with chronic heart failure
- Authors: Konenkov VI1, Poveshchenko OV1, Kim II1, Pokushalov EA2, Romanov AB2, Guleva NA1, Bernvald VV1, Shevchenko AV1, Golovanova OV1, Yankyate EV1, Poveshchenko AF1, Karaskov AM2
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Affiliations:
- Research Institute of Clinical and Experimental Lymphology SB RAMS, Novosibirsk
- State Research Institute of Circulation Pathology them. Acad. EN Meshalkina, Novosibirsk
- Issue: Vol 6, No 3 (2011)
- Pages: 71-75
- Section: Articles
- Submitted: 11.01.2023
- Published: 15.09.2011
- URL: https://genescells.ru/2313-1829/article/view/121556
- DOI: https://doi.org/10.23868/gc121556
- ID: 121556
Cite item
Abstract
cytokine-producing properties mobilized drug administration
G-CSF from bone marrow mononuclear cells of peripheral
blood of patients with heart failure, which developed after
acute myocardial infarction, in connection with the efficiency
of intramyocardial stem cell therapy. The study included 67
patients with CHD and III-IV functional class congestive
heart failure (NYHA), receiving current standard therapy.
Shown that the introduction of the drug G-CSF results in
mobilization of endothelial progenitor cells (EPC) from bone
marrow into peripheral blood (CD34+/CD133+and CD34+/
KDR+populations). Intramyocardial cell injection resulted in
improved perfusion at the injection site in 76% of patients.
Patients who responded to improved perfusion, the number of
CD34+CD133+PC in 3,2 times higher than in patients without
effect or impairment. Mononuclear cells after administration
of G-CSF in a 48 hour culture secrete cytokines, Epo,
GM-CSF, TNF-, contribute to the improvement of myocardial
perfusion. Peripheral blood is a readily available source of EPС,
and mononuclear cells after mobilization are able to exert
reparative effects on the ischemic myocardium.
About the authors
V I Konenkov
Research Institute of Clinical and Experimental Lymphology SB RAMS, NovosibirskResearch Institute of Clinical and Experimental Lymphology SB RAMS, Novosibirsk
O V Poveshchenko
Research Institute of Clinical and Experimental Lymphology SB RAMS, NovosibirskResearch Institute of Clinical and Experimental Lymphology SB RAMS, Novosibirsk
I I Kim
Research Institute of Clinical and Experimental Lymphology SB RAMS, NovosibirskResearch Institute of Clinical and Experimental Lymphology SB RAMS, Novosibirsk
E A Pokushalov
State Research Institute of Circulation Pathology them. Acad. EN Meshalkina, NovosibirskState Research Institute of Circulation Pathology them. Acad. EN Meshalkina, Novosibirsk
A B Romanov
State Research Institute of Circulation Pathology them. Acad. EN Meshalkina, NovosibirskState Research Institute of Circulation Pathology them. Acad. EN Meshalkina, Novosibirsk
N A Guleva
Research Institute of Clinical and Experimental Lymphology SB RAMS, NovosibirskResearch Institute of Clinical and Experimental Lymphology SB RAMS, Novosibirsk
V V Bernvald
Research Institute of Clinical and Experimental Lymphology SB RAMS, NovosibirskResearch Institute of Clinical and Experimental Lymphology SB RAMS, Novosibirsk
A V Shevchenko
Research Institute of Clinical and Experimental Lymphology SB RAMS, NovosibirskResearch Institute of Clinical and Experimental Lymphology SB RAMS, Novosibirsk
O V Golovanova
Research Institute of Clinical and Experimental Lymphology SB RAMS, NovosibirskResearch Institute of Clinical and Experimental Lymphology SB RAMS, Novosibirsk
E V Yankyate
Research Institute of Clinical and Experimental Lymphology SB RAMS, NovosibirskResearch Institute of Clinical and Experimental Lymphology SB RAMS, Novosibirsk
A F Poveshchenko
Research Institute of Clinical and Experimental Lymphology SB RAMS, NovosibirskResearch Institute of Clinical and Experimental Lymphology SB RAMS, Novosibirsk
A M Karaskov
State Research Institute of Circulation Pathology them. Acad. EN Meshalkina, NovosibirskState Research Institute of Circulation Pathology them. Acad. EN Meshalkina, Novosibirsk
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