The modern view on adipose tissue regenerative products potential in skin pathologies treatment

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Abstract

At this stage of regenerative medicine development, adipose tissue as a source of stem cells is the choice option due to its availability, a sufficient number of cells and the most painless sampling procedure. The high interest in this product use in scars, wounds and other dermatological diseases treatment is driven by demonstrated positive results in other medical fields.

This review presents data on the efficacy and safety of cellular and acellular adipose tissue products use in various skin pathologies treatment. Scientific literature open electronic databases PubMed (MEDLINE), Clinical Trials, and eLIBRARY.RU were used. The literature data search was carried out using the keywords: “regenerative medicine”, “SVF”, “scar”, “skin”, “dermatology”, “nanofat”, “ADSC”, “exosomes”, “lipoaspirat”.

The article presents the results and the rationale of adipose tissue regenerative products use in the most common and most significant skin diseases treatment. Cellular and acellular adipose tissue products use in dermatology and surgery is a safe and promising direction to improve skin quality. For the subsequent effective techniques application further research is needed to assess the systemic effect, as well as the development of standardized protocols for their use.

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About the authors

Anastasiya I. Greben

National Medical Research Centre for Rehabilitation and Balneology

Author for correspondence.
Email: aik-nastya@mail.ru
ORCID iD: 0000-0002-2423-523X

Junior Research Associate

Russian Federation, Moscow

Peter S. Eremin

National Medical Research Centre for Rehabilitation and Balneology

Email: ereminps@gmail.com
ORCID iD: 0000-0001-8832-8470
SPIN-code: 8597-6596

Research Associate

Russian Federation, Moscow

Elena Yu. Kostromina

National Medical Research Centre for Rehabilitation and Balneology

Email: bioimed07@hotmail.com
ORCID iD: 0000-0002-9728-7938

Cand. Sci. (Biol.), Senior Research Associate

Russian Federation, Moscow

Pavel A. Markov

National Medical Research Centre for Rehabilitation and Balneology

Email: p.a.markov@mail.ru
ORCID iD: 0000-0002-4803-4803

Cand. Sci. (Biol.), Senior Research Associate

Russian Federation, Moscow

Tatiana N. Greben

National Medical Research Centre for Rehabilitation and Balneology

Email: greben72@inbox.ru
ORCID iD: 0000-0002-6001-0804

MD

Russian Federation, Moscow

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