Endothelial progenitor cells of the bone marrow are not involved in the processes of tumor angiogenesis and are not necessary for the growth of malignant neoplasms.
- Authors: Sergeev V.S., Plaksa I.L.
- Issue: Vol 3, No 3 (2008)
- Pages: 19-21
- Section: Cell technology
- URL: https://genescells.ru/2313-1829/article/view/133725
- ID: 133725
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About the authors
V. S. Sergeev
Email: bozo.ilya@gmail.com
I. L. Plaksa
Author for correspondence.
Email: bozo.ilya@gmail.com
References
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- Нattori К., Dias S., Нeissig B. et al. Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis y recruitment of vasculogenic and hematopoietic stem cells. J. Exp. Мed. 2001; 193: 1005-14.
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Scheme for obtaining chimeric mice used in the experiment. After irradiation, wild-type mice were transplanted with bone marrow cells from transgenic mice. Depending on the promoter chosen (promoters of the b-actin, VEGF-R2, or Tie-1 genes), markers were expressed in chimeras in all bone marrow cells or only in EPCs.
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