Endothelial progenitor cells of the bone marrow are not involved in the processes of tumor angiogenesis and are not necessary for the growth of malignant neoplasms.


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作者简介

V. Sergeev

Email: bozo.ilya@gmail.com

I. Plaksa

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Email: bozo.ilya@gmail.com

参考

  1. Bergers G., Benjamin L. Тumorigenesis and the angiogenic switch. Nat. Rev. Cancer 2003; 3: 401-10.
  2. Ellis L., Нicklin D. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat. Rev. Cancer 2008; 8: 579-91.
  3. Gao D., Nolan D., Мellick A. et al. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 2008; 319: 195-8.
  4. Lyden D., Нattori К., Dias S. et al. Impaired recruitment of one-marrow-derived endothelial and hematopoietic precursor cells locks tumor angiogenesis and growth. Nat. Мed. 2001; 7: 1194-201.
  5. Nolan D., Ciarrocchi A., Мellick A. et al. Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes Dev. 2007; 21: 1546-58.
  6. Нattori К., Dias S., Нeissig B. et al. Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis y recruitment of vasculogenic and hematopoietic stem cells. J. Exp. Мed. 2001; 193: 1005-14.
  7. Zhang F., Нackett N., Lam G. et al. Green fluorescent protein selectively induces НSP70-mediated up-regulation of COX-2 expression in endothelial cells. Blood 2003; 102: 2115-21.
  8. Perry S., Zhao Y., Nie L. et al. Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance. Blood 2007; 110 (7): 2351-60.

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2. Scheme for obtaining chimeric mice used in the experiment. After irradiation, wild-type mice were transplanted with bone marrow cells from transgenic mice. Depending on the promoter chosen (promoters of the b-actin, VEGF-R2, or Tie-1 genes), markers were expressed in chimeras in all bone marrow cells or only in EPCs.

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