DEVELOPMENT OF TDPI INHIBITORS BASED ON DERIVATIVES OF CHROMENE AS POTENTIAL ANTI-CANCER DRUGS
- Authors: Chepanova A.A1, Li-Zhulanov N.S2,3, Kurgina T.A1, Zakharenko A.L1, Zakharova O.D1, Volcho K.P2,3, Salakhutdinov N.F2,3, Lavrik O.I1,3
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Affiliations:
- Novosibirsk Institute of Chemical Biology and Fundamental Medicine, SBRAS
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SBRAS
- Novosibirsk State University
- Issue: Vol 15, No 3S (2020)
- Pages: 68-69
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/122713
- DOI: https://doi.org/10.23868/gc122713
- ID: 122713
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About the authors
A. A Chepanova
Novosibirsk Institute of Chemical Biology and Fundamental Medicine, SBRAS
Email: arinachepanova@mail.ru
Russian Federation, Novosibirsk
N. S Li-Zhulanov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SBRAS; Novosibirsk State UniversityRussian Federation, Novosibirsk
T. A Kurgina
Novosibirsk Institute of Chemical Biology and Fundamental Medicine, SBRASRussian Federation, Novosibirsk
A. L Zakharenko
Novosibirsk Institute of Chemical Biology and Fundamental Medicine, SBRASRussian Federation, Novosibirsk
O. D Zakharova
Novosibirsk Institute of Chemical Biology and Fundamental Medicine, SBRASRussian Federation, Novosibirsk
K. P Volcho
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SBRAS; Novosibirsk State UniversityRussian Federation, Novosibirsk
N. F Salakhutdinov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SBRAS; Novosibirsk State UniversityRussian Federation, Novosibirsk
O. I Lavrik
Novosibirsk Institute of Chemical Biology and Fundamental Medicine, SBRAS; Novosibirsk State UniversityRussian Federation, Novosibirsk
References
- Interthal H et al., The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily. Proc Natl Acad Sci U S A. 2001;98(21):12009-14.
- Kamaletdinova T et al., The Enigmatic Function of PARP1: From PARylation Activity to PAR Readers. Cells. 2019; 8(12),1625;
- Li-Zhulanov et al., A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold. Molecules, 2018, 23(10), 2468;
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