The hipotises of the immune system's role in carcinogenesis

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The presented controversial hypothesis is an attempt to reflect on the role of the adaptive immune response in carcinogenesis. It is a well-known fact that the most of the signaling pathways which are participating in embryogenesis and regeneration are also active in tumor growth. Considering their presence in different evolutionary groups, there's such a contradiction that with same mechanisms of proliferation, animals with high regenerative potential are less predisposed to malignancy than mammals. Comparing these two groups, it's being discovered that despite the importance of immune control as a factor impeding carcinogenesis, the animals' immune system with high regenerative potential is less developed. The above is a reading of the complete or partial absence of the adaptive link of immunity. These described distinctions have formed the basis of the hypothesis of the procarcino-genic role of the adaptive immune response.

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About the authors

Y. K Slepov

I.I. MechnikovNorth-Western State Medical University


M. A Laushkin

I.I. MechnikovNorth-Western State Medical University

R. V Deev

I.I. MechnikovNorth-Western State Medical University


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