Autologic platelet-rich plasma use in varicocelectomy



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Abstract

Varicocele is a disease that is diagnosed in approximately 10% of males' population. There is data of varicocele which consider the condition as one of the most common causes of male infertility. It is only surgical treatment, to date, that is effective one. However, there is still a group of patients whose fertility problem have not been resolved with the varicocelectomy, that have led scientists to find new ways for treating male infertility. Regenerative medicine and platelet-rich plasma (PRP), in particular, have recently grown up rapidly worldwide. Many preclinical and clinical trials have already demonstrated PRP-therapy effectiveness and safety, despite the novelty of the method. This is why the interest in use PRP-therapy for treating male infertility has increased.

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About the authors

M. V Epifanova

Peoples' Friendship University of Russia; P. Hertsen Moscow Oncology Research Institute - Branch of the National Medical Research Radiological Centre

Email: epifanova_maya@mail.ru

A. A Kostin

Peoples' Friendship University of Russia; National Medical Research Radiological Centre

M. E Chalyy

Medical Research and Education Center of M.I. Lomonosov Moscow State University

B. R Gvasalia

Peoples' Friendship University of Russia

E. V Gameeva

P. Hertsen Moscow Oncology Research Institute - Branch of the National Medical Research Radiological Centre

S. A Artemenko

Central State Medical Academy of the Business Administration of the President of the Russian Federation

A. A Epifanov

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

References

  1. Noske H.D., Weidner W. Varicocele - a historical perspective. World J. Urol. 1999; 17(3): 151-7.
  2. Ivanissevich O. Left varicocele due to reflux. Experience with 4470 operative cases in forty-two years. J. Int. Coll. Surg. 1960; 34(12): 742-55.
  3. EAU Guidelines. Edn. presented at the EAU Annual Congress Copenhagen 2018. ISBN 978-94-92671-01-1.
  4. Akbay E., Cayan S., Doruk E. et al. The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents. BJU Int. 2000; 86: 490-3.
  5. Levinger U., Gornish M., Gat Y. et al. Is varicocele prevalence increasing with age? Andrologia 2007; 39: 77-80.
  6. Dabaja A.A., Goldstein M. When is a varicocele repair indicated: the dilemma of hypogonadism and erectile dysfunction? Asian J. Androl. 2016; 18(2): 213-6.
  7. Pastuszak A.W., Wang R. Varicocele and testicular function. Asian Journal of Andrology 2015; 17: 659-67.
  8. Practice Committee of the American Society for Reproductive Medicine the Society for Male Reproduction and Urology. Report on varicocele and infertility: a committee opinion. Fertility and Sterility 2014; 102(6): 1556-60.
  9. Shabana W., Teleb M., Dawod T. et al. Predictors of improvement in semen parameters after varicocelectomy for male subfertility: A prospective study. Can. Urol. Assoc. J. 2015; 9(9-10): 579-82.
  10. Chiba K., Ramasamy R., Lamb D.J. et al. The varicocele: diagnostic dilemmas, therapeutic challenges and future perspectives. Asian Journal of Andrology 2016; 18: 276-81.
  11. Santana V.P., Miranda-Furtado C.L., de Oliveira-Gennaro F.G. et al. Genetics and epigenetics of varicocele pathophysiology: an overview. J. Assist. Reprod. Genet. 2017; 34(7): 839-47.
  12. Agarwal A., Sharma R.K., Desai N.R. et al. Role of oxidative stress in pathogenesis of varicocele and infertility. Urology 2009; 73(3): 461-9.
  13. Fretz P.C., Sandlow J.I. Varicocele: current concepts in pathophysiology, diagnosis, and treatment. Urol. Clin. North Am. 2002; 29: 921-37.
  14. Mostafa T., Rashed L.A., Nabil N.I. et al. Seminal miRNA Relationship with Apoptotic Markers and Oxidative Stress in Infertile Men with Varicocele. Biomed Res. Int. 2016; 2016: 1-9.
  15. Усачева О.А. Оценка андрогенного статуса и качества эякулята у мужчин после оперативного лечения варикоцеле [диссертация]. Москва: Сеченовский Университет; 2014. [Usacheva O.A. Assessment of the health status of men after surgical treatment of varicocele [dissertation]. Moscow: Sechenov University; 2014].
  16. Santana V.P., Miranda-Furtado C.L., de Oliveira-Gennaro F.G. et al. Genetics and epigenetics of varicocele pathophysiology: an overview. J. Assist. Reprod. Genet. 2017; 34(7): 839-47.
  17. Pajovic B., Radojevic N., Dimitrovski A. et al. Advantages of micro-surgical varicocelectomy over conventional techniques. Eur. Rev. Med. Pharmacol. Sci. 2015; 19(4): 532-8.
  18. Al-Said S., Al-Naimi A., Al-Ansari A. et al. Varicocelectomy for male infertility: a comparative study of open, laparoscopic and microsurgical approaches. J. Urol. 2008; 180: 266-70.
  19. Rotker K., Sigman M. Recurrent varicocele. Asian J. Androl. 2016; 18(2): 229-33.
  20. Li F., Yamaguchi K., Okada K. et al. Significant improvement of sperm DNA quality after microsurgical repair of varicocele. Syst. Biol. Reprod. Med. 2012; 58(5): 274-7.
  21. Kirag M., Deniz N., Biri H. The Effect of Microsurgical Varicocelectomy on Semen Parameters in Men with Non-Obstructive Azoospermia. Curr. Urol. 2013; 6(3): 136-40.
  22. Leung L., Ho K.L., Tam P.C. et al. Subinguinal microsurgical varicocelectomy for male factor subfertility: ten-year experience. Hong Kong Med. J. 2013; 19(4): 334-40.
  23. Zhang J.W., Xu Q.Q., Kuang Y.L. et al. Predictors for spontaneous pregnancy after microsurgical subinguinal varicocelectomy: a prospective cohort study. Int. Urol. Nephrol. 2017; 49(6): 955-60.
  24. Peng J., Zhang Z., Cui W. et al. Spontaneous pregnancy rates in Chinese men undergoing microsurgical subinguinal varicocelectomy and possible preoperative factors affecting the outcomes. Fertil. Steril. 2015; 103(3): 635-9.
  25. Shiraishi K., Oka S., Ito H. et al. Comparison of the Results and Complications of Retroperitoneal, Microsurgical Subinguinal, and High Inguinal Approaches in the Treatment of Varicoceles. J. Androl. 2012; 33(6): 1387-93.
  26. Ding H., Tian J., Du W. et al. Open non-microsurgical, laparoscopic or open microsurgical varicocelectomy for male infertility: a meta-analysis of randomized controlled trials. BJU Int. 2012; 110(10): 1536-42.
  27. Bryniarski P., Taborowski P., Rajwa P. et al. The comparison of laparoscopic and microsurgical varicocoelectomy in infertile men with varico-coele on paternity rate 12 months after surgery: a prospective randomized controlled trial. Andrology 2017; 5(3): 445-50.
  28. Scarcia M., Maselli F.P., Cardo G. et al. The use of autologous platelet rich plasma gel in bulbar and penile buccal mucosa urethroplasty: Preliminary report of our first series. Arch. Ital. Urol. Androl. 2016; 88(4): 274-8.
  29. Shirvan M.K., Alamdari D.H., Ghoreifi A. A novel method for iatrogenic vesicovaginal fistula treatment: autologous platelet rich plasma injection and platelet rich fibrin glue interposition. J. Urol. 2013; 189(6): 2125-9.
  30. Cameli N., Mariano M., Cordone I. et al. Autologous Pure Platelet-Rich Plasma Dermal Injections for Facial Skin Rejuvenation: Clinical, Instrumental, and Flow Cytometry Assessment. Dermatol. Surg. 2017; 43(6): 826-35.
  31. Anitua E., Muruzabal F., de la Fuente M. et al. Plasma Rich in Growth Factors for the Treatment of Ocular Surface Diseases. Curr. Eye Res. 2016; 41(7): 875-82.
  32. Foster T.E., Puskas B.L., Mandelbaum B.R. et al. Platelet-rich plasma from basic science to clinical applications. Am.J. Sports Med. 2009; 37(11): 2259-72.
  33. Daif E.T. Effect of autologous platelet-rich plasma on bone regeneration in mandibular fractures. Dent. Traumatol. 2013; 29(5): 399-403.
  34. Sadeghi-Ataabadi M., Mostafavi-Pour Z., Vojdani Z. et al. Fabrication and characterization of platelet-rich plasma scaffolds for tissue engineering applications. Mater. Sci. Eng. C. Mater. Biol. Appl. 2017; 71: 372-80.
  35. Anjayani S., Wirohadidjojo Y.W., Adam A.M. et al. Sensory improvement of leprosy peripheral neuropathy in patients treated with perineural injection of platelet-rich plasma. Int. J. Dermatol. 2014; 53(1): 109-13.
  36. Teymur H., Tiftikcioglu Y.O., Cavusoglu T. et al. Effect of platelet-rich plasma on reconstruction with nerve autografts. Kaohsiung J. Med. Sci. 2017; 33(2): 69-77.
  37. Enderami S.E., Mortazavi Y., Soleimani M. et al. Generation of Insulin-Producing Cells From Human-Induced Pluripotent Stem Cells Using a Stepwise Differentiation Protocol Optimized With Platelet-Rich Plasma. J. Cell. Physiol. 2017; 232(10): 2878-86.
  38. Ahmed M., Reffat S.A., Hassan A. et al. Platelet Rich Plasma for the Treatment of Clean Diabetic Foot Ulcers. Ann. Vasc. Surg. 2017; 38: 206-11.
  39. Choi J., Minn K.W., Chang H. The Efficacy and Safety of Platelet-Rich Plasma and Adipose-Derived Stem Cells: An Update. Arch. Plast. Surg. 2012; 39(6): 585-92.
  40. Marx R.E. Platelet-rich plasma: evidence to support its use. J. Oral Maxillofac. Surg. 2004; 62(4): 489-96.
  41. Cohn C.S., Lockhart E. Autologous platelet-rich plasma: evidence for clinical use. Curr. Opin. Hematol. 2015; 22(6): 527-32.
  42. Redler L.H., Thompson S.A., Hsu S.H. et al. Platelet-rich plasma therapy: a systematic literature review and evidence for clinical use. Phys. Sportsmed 2011; 39(1): 42-51.
  43. Dohan Ehrenfest D.M., Andia I., Zumstein M.A. et al. Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles, Ligaments Tendons J. 2014; 4(1): 3-9.
  44. Pavlovic V., Ciric M., Jovanovic V. et al. Platelet Rich Plasma: a short overview of certain bioactive components. Open Medicine 2016; 11(1): 242-7.
  45. Epifanova M.V., Gvasalia B.R., Durashov M.A. et al. Platelet-Rich Plasma Therapy for Male Sexual Dysfunction: Myth or Reality? Sex. Med. Rev. 2020; 8: 106-113.
  46. Чалый М.Е., Вилькин Я.Ф., Епифанова М.В. Способ лечения эректильной дисфункции. Патент РФ на изобр. № 2514639. 05 марта 2014.
  47. Epifanova M., Gvasalia B., Durashov M. et al. Safety and effectiveness of platelet-rich plasma for male infertility improvement in rats. The Journal of Urology 2019; 201(4): 765.
  48. Tek M., Cayan S., Yilmaz N. et al. The effect of vascular endothelial growth factor on spermatogenesis and apoptosis in experimentally varicocele-induced adolescent rats. Fertil. Steril. 2009; 91(5): 2247-52.
  49. Zaporozhan V., Kholodkova O., Kuleshova O. Platelet-rich plasma induces morphofunctional restoration of mice testes following doxorubomycine hydrochloride exposure. Journal of Experimental and Clinical Medicine 2014; 31(3): 183-7.
  50. Sekerci C.A., Tanidir Y., Sener T.E. et al. Effects of platelet-rich plasma against experimental ischemia/reperfusion injury in rat testis. J. Pediatr. Urol. 2017; 13(3): 317.
  51. ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000 Feb 29-. Identifier NCT02708537, Effect of Plasma Rich in Growth Factors on Semen Quality; 2016 Mar 15, [cited 2019 Nov 30] Available from: https://clinicaltrials.gov/ct2/show/NCT02708537
  52. Al-Nasser R., Khrait Z., Jamali S. The Effectiveness of Autologous Platelet-Rich Plasma (PRP) in the Therapy of Infertile Men with Non-Abstractive.
  53. Azoospermia. J. Reprod. Med. Gynecol. Obstet. 2018; 3: 011.
  54. Dudek R., Fix J. High-Yield Embryology. In: Dudek R., Fix J., editors. Urinary system, Female reproductive system. 3rd ed. Baltimore: Lippincott Williams and Wilkins; 2005. р. 137-56.
  55. Bakacak M., Bostanci M.S., inanc F. et al. Protective Effect of Platelet Rich Plasma on Experimental Ischemia/Reperfusion Injury in Rat Ovary. Gynecol. Obstet. Invest. 2016; 81(3): 225-31.
  56. Pantos K., Nitsos N., Kokkali G. et al. Ovarian rejuvenation and folliculogenesis reactivation in peri-menopausal women after autologous platelet-rich plasma treatment. Human Reproduction 2016; 31(1): 301.
  57. ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000 Feb 29-. Identifier NCT03178695, Inovium Ovarian Rejuvenation Trials; 2017 June 7, [cited 2019 Nov 30] Available from: https://clinicaltrials.gov/ct2/show/NCT03178695.

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