Heart valve tissue engineering: decellularization of allo- and xenografts

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Abstract

Implantation of artifitial heart valve prostheses is assotiated
with several serious complications. Therefore, there is a need
in new approaches of preparing heart valve prostheses.
One of such approaches is heart valve tissue engineering.
Tissue engineered heart valves are to be biocompatible,
durable, long-life, no necessity in anti-trombotic therapy, and
they have potential to grow and regenerate with host. The
most developed method of heart valve tissue engineering is
decellularization, i.e. preparing an extracellular matrix, which
has potential in recellularize with stem host-cells and then
implant it. This review focuses on methods of decellularization
of heart valves and their ability to change structural and
biomechanical properties of allo- and xenografts.

About the authors

D I Kurapeev

V.A. Almazov Federal Heart, Blood and Endocrinology Centre, Saint PetersburgInstitute of Experimental Medicine RAMS, Saint Petersburg

V.A. Almazov Federal Heart, Blood and Endocrinology Centre, Saint PetersburgInstitute of Experimental Medicine RAMS, Saint Petersburg

A V Lavreshin

V.A. Almazov Federal Heart, Blood and Endocrinology Centre, Saint PetersburgInstitute of Experimental Medicine RAMS, Saint Petersburg

V.A. Almazov Federal Heart, Blood and Endocrinology Centre, Saint PetersburgInstitute of Experimental Medicine RAMS, Saint Petersburg

S V Anisimov

V.A. Almazov Federal Heart, Blood and Endocrinology Centre, Saint Petersburg

V.A. Almazov Federal Heart, Blood and Endocrinology Centre, Saint Petersburg

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