Application of nanocomposite coatings for multipotent mesenchymal stromal cells cultivation technologies

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Abstract

The results of experimental research for the effect character of nanocomposite coatings with different physicochemical parameters on structural and functional properties (adhesive potential, phenotype, expression of ido gene) of multipotent mesenchymal stromal cells (MMSCs) are presented in the work. In the whole spectrum of tested nanocoatings (Al 2O 3, ZrO 2, Ta 2O 5) we have established the ability of oxide coating Al2O3 to monolayerly enrich the cultured in vitro bone marrow (BM) with the MMSCs and increase the degree of ido expression. This can expand the spectrum and give them new shapes of therapeutic potential in clinical practice.

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About the authors

A. N Goltsev

Institute for Problems of Cryobiology and Cryomedicine of the NAS, Kharkov, Ukraine

I. V Rassokha

Institute for Problems of Cryobiology and Cryomedicine of the NAS, Kharkov, Ukraine

T. G Dubrava

Institute for Problems of Cryobiology and Cryomedicine of the NAS, Kharkov, Ukraine

L. V Ostankova

Institute for Problems of Cryobiology and Cryomedicine of the NAS, Kharkov, Ukraine

M. V Ostankov

Institute for Problems of Cryobiology and Cryomedicine of the NAS, Kharkov, Ukraine

E. A Gordienko

Institute for Problems of Cryobiology and Cryomedicine of the NAS, Kharkov, Ukraine

V. I Safonov

National Scientific Center «Kharkov Physico-Technical Institute» of the NAS, Kharkov, Ukraine

AV. V Zykova

National Scientific Center «Kharkov Physico-Technical Institute» of the NAS, Kharkov, Ukraine

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