Role of VEGF-A165 receptors in angiogenesis

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We present an overview of current literature data on the different roles of key proangiogenic factor VEGF-A-165' receptors in angiogenesis regulation. VEGFR2 is the major effector receptor and runs intracellular cascades that provide survival, proliferation and migration of endothelial cells, the involvement of progenitor cells, the formation and maturation of new blood vessels. VEGFR1 contrary is the main regulator of the activity of VEGF-A-165, preventing excessive angiogenic response through the mechanism of negative feedback. The article also presents data on the variability of number and ratio of VEGFR1 and VEGFR2 on the surface of different cell types, providing the fine regulation of the VEGF-A-165 pathway.

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About the authors

I. V Arutyunyan

esearch Center for Obstetrics, Gynecology and Perinatology MH of RF, Moscow; Research Institute of Human Morphology of the RAMS, Moscow

E. Y Kananykhina

Research Institute of Human Morphology of the RAMS, Moscow

A. V Makarov

esearch Center for Obstetrics, Gynecology and Perinatology MH of RF, Moscow; Research Institute of Human Morphology of the RAMS, Moscow


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