Influence of serum antibodies to DNA on theMadin-Darby сanine kidney epithelial cells in vitroin depend of immunoreactive regions of the IgG molecule
- Authors: Ivanov, VV1, Nevzorova TA1
-
Affiliations:
- Кazan (Volga region) Federal University, Kazan
- Issue: Vol 7, No 3 (2012)
- Pages: 66-68
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121585
- DOI: https://doi.org/10.23868/gc121585
- ID: 121585
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Abstract
The data obtained on cell lines MDCK showed that for
implementation of the biological function of antibodies to DNA
both normal and pathological need the participation as Fab- and
Fc-fragments of molecules of IgG. However, antigen-binding
region is responsible for the manifestation of the biological
function of SLE antibodies to DNA more immunoreactive
than antibodies in normal and constant region is probably
responsible for the active conformation of antibody for pathobiological
function of antibodies to DNA in the cell.
implementation of the biological function of antibodies to DNA
both normal and pathological need the participation as Fab- and
Fc-fragments of molecules of IgG. However, antigen-binding
region is responsible for the manifestation of the biological
function of SLE antibodies to DNA more immunoreactive
than antibodies in normal and constant region is probably
responsible for the active conformation of antibody for pathobiological
function of antibodies to DNA in the cell.
Keywords
About the authors
V V Ivanov,
Кazan (Volga region) Federal University, KazanКazan (Volga region) Federal University, Kazan
T A Nevzorova
Кazan (Volga region) Federal University, KazanКazan (Volga region) Federal University, Kazan
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