Can pancreas be the source of hepatocytes?
- Authors: Abdulkhakova AR1, Abdulkhakov SR1, Titova MA1,2,3, Saifullina KN1, Gumerova AA1,2,3, Kiasov AP1,2,3
-
Affiliations:
- Кazan State Medical University, Kazan
- Кazan (Volga region) Federal University, Kazan
- Issue: Vol 7, No 3 (2012)
- Pages: 21-24
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121565
- DOI: https://doi.org/10.23868/gc121565
- ID: 121565
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Abstract
The possibility of hepatocytes differentiation from
pancreatic cells is discussed in the review. Both liver
and pancreas develop from endoderm so there could be a
common stem cell giving rise to both pancreatic and liver
cells. Different experimental models are used to study
the possibility of hepatocytes development in pancreas
such as influence of peroxisomes proliferation stimulators,
hyperexpression of keratinocyte growth factor in pancreatic
islets, Cu depletion-repletion model, etc.). There is no
enough data to confirm which particular pancreatic cell type
can be the source of hepatocytes.
Literature data allow supposing that hepatocytes can
arise in pancreas from three different sources: acinar,
endocrine or ductular cells.
pancreatic cells is discussed in the review. Both liver
and pancreas develop from endoderm so there could be a
common stem cell giving rise to both pancreatic and liver
cells. Different experimental models are used to study
the possibility of hepatocytes development in pancreas
such as influence of peroxisomes proliferation stimulators,
hyperexpression of keratinocyte growth factor in pancreatic
islets, Cu depletion-repletion model, etc.). There is no
enough data to confirm which particular pancreatic cell type
can be the source of hepatocytes.
Literature data allow supposing that hepatocytes can
arise in pancreas from three different sources: acinar,
endocrine or ductular cells.
Keywords
About the authors
A R Abdulkhakova
Кazan State Medical University, KazanКazan State Medical University, Kazan
S R Abdulkhakov
Кazan State Medical University, KazanКazan State Medical University, Kazan
M A Titova
Кazan State Medical University, Kazan;Кazan (Volga region) Federal University, Kazan;Кazan State Medical University, Kazan;Кazan (Volga region) Federal University, Kazan;
K N Saifullina
Кazan State Medical University, KazanКazan State Medical University, Kazan
A A Gumerova
Кazan State Medical University, Kazan;Кazan (Volga region) Federal University, Kazan;Кazan State Medical University, Kazan;Кazan (Volga region) Federal University, Kazan;
A P Kiasov
Кazan State Medical University, Kazan;Кazan (Volga region) Federal University, Kazan;Кazan State Medical University, Kazan;Кazan (Volga region) Federal University, Kazan;
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