Znachenie ekspressii TLR-retseptorov dlya vybora farmakologicheskoy korrektsii patologii sheyki matki i endometriya



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Abstract

В работе проведено иммуноцитохимическое исследование клеточного материала, полученного методом жидкостной цитологии из эктоцервикса, эндоцервикса у пациенток с персистирующей папилломавирусной инфекцией, инфицированных вирусами, относящимися к высокой группе онкогенного риска, и из эндометрия женщин, страдающих бесплодием до и после лечения нуклеосперматом натрия (нуклеоспермат-Na). Иммуноцитохимическое исследование материала проводилось с использованием моноклональных антител к CD20, CD56 и Toll-like рецепторам. После лечения нуклеосперматом натрия было зарегистрировано снижение частоты CD20 и CD56-позитивных клеток и повышение частоты клеток, экспрессирующих Toll-like рецепторы 4-го и 9-го типов в исследуемом материале, а также снижение количества вируса папилломы человека высокого онкогенного риска. Полученные результаты указывают на перспективность использования нуклеоспермата натрия в лечении бесплодия, ассоциированного с хроническим аутоиммунным эндометритом, что убедительно подтверждено иммуноцитохимическим исследованием.

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References

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