Stimulation of rats sciatic nerve post-traumatic regeneration using plasmids expressing vascular endothelialgrowth factor and basic fibroblast growth factor
- Authors: Masgutov RF1, Salafutdinov II2, Bogov AA3, Trofimova AA2, Khannanova IG4, Mullin RI4, Islamov RR5, Chelyshev Y.A5, Bogov AA4, Rizvanov AA1
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Affiliations:
- Republic Clinical Hospital, KazanKazan (Volga Region) Federal University, KazanKazan State Medical University, Kazan
- Republic Clinical Hospital, KazanKazan (Volga Region) Federal University, Kazan
- Kazan State Medical University, Kazan
- Republic Clinical Hospital, Kazan
- Kazan (Volga Region) Federal University, KazanKazan State Medical University, Kazan
- Issue: Vol 6, No 3 (2011)
- Pages: 67-70
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121554
- DOI: https://doi.org/10.23868/gc121554
- ID: 121554
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Abstract
with peripheral nerve injury is an urgent task of biomedicine.
«Gold» standard in restoring the integrity of nerve conduits is
auto-nerve transplantation in which a peripheral nerve defect
is corrected with autologous nerve graft. Here we propose
a method for stimulating revascularization and regeneration
of auto-nerve graft by a local injection of plasmid pBud-VEGFFGF2,
expressing vascular endothelial growth factor (VEGF)
and basic fibroblast growth factor (FGF2). It is shown that
direct injection of plasmid pBud-VEGF-FGF2 in the proximal
and distal segments of nerve, as well as in the auto-nerve
graft, stimulates the regeneration of the rats sciatic nerve
and restores motor activity.
About the authors
R F Masgutov
Republic Clinical Hospital, KazanKazan (Volga Region) Federal University, KazanKazan State Medical University, KazanRepublic Clinical Hospital, KazanKazan (Volga Region) Federal University, KazanKazan State Medical University, Kazan
I I Salafutdinov
Republic Clinical Hospital, KazanKazan (Volga Region) Federal University, KazanRepublic Clinical Hospital, KazanKazan (Volga Region) Federal University, Kazan
A A Bogov
Kazan State Medical University, KazanKazan State Medical University, Kazan
A A Trofimova
Republic Clinical Hospital, KazanKazan (Volga Region) Federal University, KazanRepublic Clinical Hospital, KazanKazan (Volga Region) Federal University, Kazan
I G Khannanova
Republic Clinical Hospital, KazanRepublic Clinical Hospital, Kazan
R I Mullin
Republic Clinical Hospital, KazanRepublic Clinical Hospital, Kazan
R R Islamov
Kazan (Volga Region) Federal University, KazanKazan State Medical University, KazanKazan (Volga Region) Federal University, KazanKazan State Medical University, Kazan
Yu A Chelyshev
Kazan (Volga Region) Federal University, KazanKazan State Medical University, KazanKazan (Volga Region) Federal University, KazanKazan State Medical University, Kazan
A A Bogov
Republic Clinical Hospital, KazanRepublic Clinical Hospital, Kazan
A A Rizvanov
Republic Clinical Hospital, KazanKazan (Volga Region) Federal University, KazanKazan State Medical University, KazanRepublic Clinical Hospital, KazanKazan (Volga Region) Federal University, KazanKazan State Medical University, Kazan
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