Stimulation of rats sciatic nerve post-traumatic regeneration using plasmids expressing vascular endothelialgrowth factor and basic fibroblast growth factor
- 作者: Masgutov RF1, Salafutdinov II2, Bogov AA3, Trofimova AA2, Khannanova IG4, Mullin RI4, Islamov RR5, Chelyshev Y.A5, Bogov AA4, Rizvanov AA1
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隶属关系:
- Republic Clinical Hospital, KazanKazan (Volga Region) Federal University, KazanKazan State Medical University, Kazan
- Republic Clinical Hospital, KazanKazan (Volga Region) Federal University, Kazan
- Kazan State Medical University, Kazan
- Republic Clinical Hospital, Kazan
- Kazan (Volga Region) Federal University, KazanKazan State Medical University, Kazan
- 期: 卷 6, 编号 3 (2011)
- 页面: 67-70
- 栏目: Articles
- ##submission.dateSubmitted##: 11.01.2023
- ##submission.datePublished##: 15.09.2011
- URL: https://genescells.ru/2313-1829/article/view/121554
- DOI: https://doi.org/10.23868/gc121554
- ID: 121554
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详细
with peripheral nerve injury is an urgent task of biomedicine.
«Gold» standard in restoring the integrity of nerve conduits is
auto-nerve transplantation in which a peripheral nerve defect
is corrected with autologous nerve graft. Here we propose
a method for stimulating revascularization and regeneration
of auto-nerve graft by a local injection of plasmid pBud-VEGFFGF2,
expressing vascular endothelial growth factor (VEGF)
and basic fibroblast growth factor (FGF2). It is shown that
direct injection of plasmid pBud-VEGF-FGF2 in the proximal
and distal segments of nerve, as well as in the auto-nerve
graft, stimulates the regeneration of the rats sciatic nerve
and restores motor activity.
作者简介
R Masgutov
Republic Clinical Hospital, KazanKazan (Volga Region) Federal University, KazanKazan State Medical University, KazanRepublic Clinical Hospital, KazanKazan (Volga Region) Federal University, KazanKazan State Medical University, Kazan
I Salafutdinov
Republic Clinical Hospital, KazanKazan (Volga Region) Federal University, KazanRepublic Clinical Hospital, KazanKazan (Volga Region) Federal University, Kazan
A Bogov
Kazan State Medical University, KazanKazan State Medical University, Kazan
A Trofimova
Republic Clinical Hospital, KazanKazan (Volga Region) Federal University, KazanRepublic Clinical Hospital, KazanKazan (Volga Region) Federal University, Kazan
I Khannanova
Republic Clinical Hospital, KazanRepublic Clinical Hospital, Kazan
R Mullin
Republic Clinical Hospital, KazanRepublic Clinical Hospital, Kazan
R Islamov
Kazan (Volga Region) Federal University, KazanKazan State Medical University, KazanKazan (Volga Region) Federal University, KazanKazan State Medical University, Kazan
Yu Chelyshev
Kazan (Volga Region) Federal University, KazanKazan State Medical University, KazanKazan (Volga Region) Federal University, KazanKazan State Medical University, Kazan
A Bogov
Republic Clinical Hospital, KazanRepublic Clinical Hospital, Kazan
A Rizvanov
Republic Clinical Hospital, KazanKazan (Volga Region) Federal University, KazanKazan State Medical University, KazanRepublic Clinical Hospital, KazanKazan (Volga Region) Federal University, KazanKazan State Medical University, Kazan
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