Proliferative processes and features of tumor cell receptor apparatus of the breast carcinoma

Cell division in tumor tissue is associated not only with the growth rate of the tumor, but also its response to ongoing chemotherapy. The isolated subtypes of breast carcinoma differ significantly in the prognosis of the disease, but up to now the level of proliferative processes is only taken into account when dividing the Luminal variants. The aim of the study was to analyze the relationship between the level of proliferative processes in the tumor tissue of breast carcinoma in different tumor subtypes, analyze the patterns of proliferation activity and the characteristics of the receptor apparatus of cells. Material investigated 672 cases of breast invasive carcinomas. In all cases investigated by immunohistochemistry proliferative activity index Ki-67 tumor, as well as steroid hormone receptors ER, PR, and HER-2 / neu receptor. All the cases were divided into biological subtypes according to the standard classification. Mid proliferation index Ki-67 group luminal subtype tumors equaled 8,4±0,2%, in the luminal (HER-2 positive) subtype - 28,8±2,5%, in the luminal (HER-2 negative) subtype - 32,3±1,0%, HER-2 positive subtype - 39,0±2,2%, triple negative subtype - 54,6±2,1% tumors (p <0,05), with the exception of groups in luminal tumors (HER-2 negative) and In the luminal (HER-2 positive) biological subtypes (p> 0,05). Significant differences in proliferation between all treatment groups. The lowest level of proliferation characteristic luminal subtype of breast carcinoma (8.4%), most proliferating tumors are triple negative subtype (Ki-67 = 54.6%). The results show low proliferation of tumors in luminal A subtype of breast carcinoma, as well as a high tumor proliferation in such biological subtypes as luminal B (HER2-positive), luminal B (HER2-negative), HER2 positive and triple negative, and the highest level of expression of Ki-67 observed in carcinomas of triple negative subtype. The observed differences in proliferation levels determined by the expression level of Ki-67 between the subtypes of the breast cancer associated with differences in the receptor apparatus of tumor cells allow us not only to clarify the intracellular mechanisms of cell proliferation in tumor tissue, but also to recommend taking them into account as an additional diagnostic criterion for matching the level Proliferation of the receptor status of tumor cells within each of the subtypes of the breast cancer.

Ki-67, proliferative index, proliferation, Ki-67, breast cancer, biological subtypes, immunohistochemical study