Ethical and scientific aspects of human embryonic material research: the Great Britain regulations

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Abstract

We analyze the ethical and scientific issues of human embryonic specimen and its utilization for research purposes. Human embryonic specimens are the source of stem cells which are the foundation for all organs and tissue formation. The analysis of human embryonic specimens promises to obtain the essential knowledge about human development and reveal the causes of human development pathology. Ethical and scientific problems of human embryonic specimens donation and research are debated here We review the impact that human embryonic specimens impose on scientific research, usage restrictions, risk assessment, research personnel and donor protection in view of the British, and other European publications, case reports, legislation, regulations and guidelines This work is focused on the discussion of different aspects of donation and usage of human embryonic specimens obtained after the elective medical termination of pregnancy We discuss suggestions for improvement of the ethical and scientific regulations for the work with human embryonic donor material in Russian Federation.

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About the authors

S. A Rybtsov

Scottish Centre for Regenerative Medicine of the University of Edinburgh

Email: srybtsov@staffmail.ed.ac.uk

E. V Dumacheva

Institute of Management of the Belgorod National Research University

D. V Dumachev

Institute of Medicine of the Belgorod National Research University

I. G Mustafin

Kazan State Medical University

A. M Kagansky

Human Genetics Unit of the Institute of Genetics and Molecular Medicine, Western General Hospital of the Edinburgh

N. N Rybtsova

Scottish Centre for Regenerative Medicine of the University of Edinburgh

R. I Zhdanov

Institute for Advanced Study of the Moscow State Pedagogical University; Institute of Fundamental Medicine and Biology of the Kazan (Volga region) Federal University

References

  1. Fischbach G.D., Fischbach R.L. Stem cells: science, policy, and ethics. J. Clin. Investig. 2004; 114(10): 1364-70.
  2. Thomson J.A., Itskovitz-Eldor J., Shapiro S.S. et al. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282(53913:1145-7.
  3. Lerou P.H., Daley G.Q. Therapeutic potential of embryonic stem cells. Blood Reviews 2005; 19(6): 321-31.
  4. Киселев С.Л., Лагарькова М.А. Эмбриональные стволовые клетки человека. Природа 2006; 10: 49-64.
  5. Филоненко Е.С., Лагарькова М.А., Киселев С.Л. Перспективы использования плюрипотентных стволовых клеток человека для получения компонентов крови: Эритропоэз. Гены и клетки 2013; VIII(2): 6-12.
  6. Богомазова А.Н., Васина Е.М., Киселев С.Л. и соавт. Генетическое репрограммирование клеток: новая технология для фундаментальных исследований и практического использования. Генетика 2015; 51(4): 466.
  7. Fonseca S.A., Costas R.M., Pereira L.V. Searching for naive human pluripotent stem cells. World J. Stem Cells 2015; 7(3): 649-56
  8. Takahashi K., Tanabe K., Ohnuki M. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 2007; 131(5): 861-72.
  9. Lujan E., Chanda S., Ahlenius H. et al. Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells PNAS USA 2012; 109(7): 2527-32.
  10. Bredenkamp N., Ulyanchenko S., O'Neill K.E. et al. An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts. Nat. Cell Biol. 2014; 16(9): 902-8.
  11. Riddell J., Gazit R., Garrison B.S. et al. Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell 2014; 157(3): 549-64.
  12. Daley G.Q., Ahrlund Richter L., Auerbach J.M. et al. Ethics. The ISSCR guidelines for human embryonic stem cell research. Science 2007; 315(5812): 603-4.
  13. Carlson B.M. Human Embryology and Developmental Biology. St. Louis: Mosby; 2004.
  14. van den Berg J., Gordon B.B., Snijders M.P. et al. The added value of mifepristone to non-surgical treatment regimens for uterine evacuation in case of early pregnancy failure: a systematic review of the literature. Euro. J. Obstet. Gynecol. Repr. Biol. 2015; 195(30): 18-26.
  15. Ngo T.D., Park M.H., Shakur H. et al. Comparative effectiveness, safety and acceptability of medical abortion at home and in a clinic: a systematic review. Bull. World Health Org. 2011; 89(5): 360-70.
  16. O'Rahilly R., Müller F. Developmental stages in human embryos. Washington: Carnegie Institution of Washington; 1987.
  17. Ivanovs A., Rybtsov S., Welch L. et al. Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region. J. Exp. Med. 2011; 208(12): 2417-27.
  18. Ivanovs A., Rybtsov S., Anderson R.A. et al. Identification of the niche and phenotype of the first human hematopoietic stem cells Stem Cell Reports 2014; 2(4): 449-56.
  19. Ivanovs A., Rybtsov S., Anderson R.A. et al. Postmenstrual gestational age should be used with care in studies of early human hematopoietic development. Blood 2013; 121(15): 3051-2.
  20. Fang H., Yang Y., Li C. et al. Transcriptome analysis of early organogenesis in human embryos. Develop. Cell 2010; 19(1): 174-84.
  21. Farley A.M., Morris L.X., Vroegindeweij E. et al. Dynamics of thymus organogenesis and colonization in early human development Development 2013; 140(9): 2015-26.
  22. Jennings R.E., Berry A.A., Strutt J.P. et al. Human pancreas development. Development 2015; 142(18): 3126-37.
  23. Jennings R.E., Berry A.A., Kirkwood-Wilson R. et al. Development of the human pancreas from foregut to endocrine commitment. Diabetes 2013; 62(10): 3514-22.
  24. O'Rahilly R., Muller F. Developmental stages in human embryos: revised and new measurements. Cells, Tissues, Organs 2010; 192(2): 73-84.
  25. Hug K. Research on human-animal entities: ethical and regulatory aspects in Europe. Stem Cell Review 2009; 5(3): 181-94.
  26. de Wert G., Mummery C. Human embryonic stem cells: research, ethics and policy. Human Repr. 2003; 18(4): 672-82.
  27. Hug K., Hermerén G. Origins, ethics and embryos: the sources of human embryonic stem cells. EuroStemCell 2015. http://www. eurostemcell. org/factsheet/origins-ethics-and-embryos-sources-human-embryonic-stem-cells
  28. Regulation of stem cell research in Europe. EuroStemCell 2008-2015. http://www. eurostemcell. org/stem-cell-regulations.
  29. Committee on Guidelines for Human Embryonic Stem Cell Research [US]. Guidelines for Human Embryonic Stem Cell Research ISSCR. Washington: The National Academies Press; 2005.
  30. Bioethics: Human-animal hybrid embryos. United Kingdom: BBC 2014. http://www.bbc.co.uk/ethics/animals/using/hybridembryos_1. shtml
  31. Plomer A., Torremans P., editors. Embryonic Stem Cell Patents: European Law and Ethics. Oxford [UK]: Oxford University press; 2009
  32. Hermerén G. Stem cell patents: ethical aspects. 2011. http:// www eurostemcell org/commentanalysis/stem-cell-patents-ethical-aspects
  33. Small S., Doherty K. Regulation of stem cell research in the United Kingdom 2008-2015. http://www. eurostemcell.org/ regulations/regulation-stem-cell-research-united-kingdom
  34. MRC ethics series Human Tissue and Biological Samples for Use in Research: Operational and Ethical Guidelines. Medical Research Council 2014. http://www.mrc.ac.uk/news/publications/human-tissue-and-biological-samples-for-use-in-research/
  35. Lewis R., Zhdanov R.I. Centenarians as stem cell donors. AJOB 2009; 9(11): 1-3.
  36. Hug K. Sources of human embryos for stem cell research: ethical problems and their possible solutions Medicina (Kaunas) 2005; 41(12): 1002-10.
  37. Ivanovs A., Rybtsov S., Welch L. et al. Highly potent human haemopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region. The Lancet 2013; 381: 12.
  38. Keown J. The Polkinghorne Report on Fetal Research: nice recommendations, shame about the reasoning. J. Med. Ethic. 1993; 19(2): 114-20.
  39. Human Fertilisation and Embryology Act 1990. London: The National Archives 1990. http://www. legislation.gov.uk/ ukpga/1990/37/contents.
  40. Eckstein S., editor. Manual for research ethics committees. 6th ed. London [UK]: Cambridge University press; 2003.
  41. Data protection act 1998. London: The National Archives 1998. http://www. legislation. gov. uk/ukpga/1998/29.
  42. Weale A.R., Lear P.A. Organ transplantation and the Human Tissue Act. Postgrad. Med. J. 2007; 83(977): 141-2.
  43. Human Tissue Act 2004. London: The National Archives 2004. http://www. legislation. gov. uk/ukpga/2004/30/contents.
  44. Abortion Act 1967. London: TSO (The Stationery Office) 1967. http://www. legislation. gov. uk/ukpga/1967/87/contents.
  45. Conversations: ethics, science, stem cells. EuroStemCell 2013.
  46. Crick expert warns against impractical ban on genetic editing of embryos: Science news 2015. https://www. crick. ac. uk/news/ science-news/2015/04/24/genetic-editing-of-embryos/
  47. Connor S. First licence to genetically modify human embryos could revolutionise IVF treatments, scientists say. Independent 2016. http://www. independent. co. uk/news/science/first-licence-to-genetically-modify-human-embryos-could-revolutionise-ivf-treatments-scientists-say-a6846581. html
  48. Swiers G., Rode C., Azzoni E. et al. A short history of hemogenic endothelium. Blood Cells, Mol. Diseas. 2013; 51(4): 206-12.
  49. Shi Q., VandeBerg J.L. Experimental approaches to derive CD34+ progenitors from human and nonhuman primate embryonic stem cells. Amer. J. Stem Cells 2015; 4(1): 32-7.
  50. Dieterlen-Lievre F. On the origin of haemopoietic stem cells in the avian embryo: an experimental approach. J. Embryol. Exper. Morphol. 1975; 33(3): 607-19.
  51. Ciau-Uitz A., Liu F., Patient R. Genetic control of hematopoietic development in Xenopus and zebrafish. Inter. J. Dev. Biol. 2010; 54(6-7): 1139-49.
  52. Ivanovs A., Medvinsky A. In search of human hematopoietic stem cell identity. Cell Stem Cell 2015; 16(1): 5-6.
  53. Shultz L.D., Lyons B.L., Burzenski L.M. et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J. Immunol. 2005; 174(10): 6477-89.
  54. Ballen K.K., Gluckman E., Broxmeyer H.E. Umbilical cord blood transplantation: the first 25 years and beyond. Blood 2013; 122(4): 491-8.
  55. Troeger C., Surbek D., Schoberlein A. et al. In utero haematopoietic stem cell transplantation. Experiences in mice, sheep and humans. Swiss Med. Week. 2006; 136(31-32): 498-503
  56. Lan P., Tonomura N., Shimizu A. et al. Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation. Blood 2006; 108(2): 487-92.
  57. Roy N.S., Cleren C., Singh S.K. et al. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat. Med. 2006; 12(11): 1259-68.
  58. Проект Федерального закона "О биомедицинских клеточных продуктах" принят в первом чтении. Министерство здравохранения РФ 2015. http://www.rosminzdrav.ru/news/2015/04/21/2311-proekt-federalnogo-zakona-o-biomeditsinskih-kletochnyh-produktah-prinyat-v-pervom-chtenii

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