Current ideas about the a-cells population and their role in the pathogenesis of diabetes mellitus
- Authors: Plushkina A.S1, Kaligin M.S1
-
Affiliations:
- Kazan (Volga region) Federal University
- Issue: Vol 10, No 4 (2015)
- Pages: 20-22
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/120472
- DOI: https://doi.org/10.23868/gc120472
- ID: 120472
Cite item
Open Access
Access granted
Abstract
Diabetes mellitus is a global problem of modern medicine All over the world scientists are study this disease in order to find new and effective therapies Numerous studies in recent years show very important role of glucagon, a hormone produced by α-cells of pancreas, in the pathogenesis of hyperglycemia in diabetes mellitus. The review analyzed current ideas about the features of the formation and differentiation of α- and β-cells of the pancreas. Particular attention is given to α-cells population and their role in the development of hyperglycemia in diabetes mellitus.
Keywords
Full Text
About the authors
A. S Plushkina
Kazan (Volga region) Federal University
Email: ob_alexa@mail.ru
M. S Kaligin
Kazan (Volga region) Federal University
References
- Whiting D. R., Guariguata L., Weil C. et al. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res. Clin. Pract. 2011; 94(3): 311-21.
- Потемкин В.В. Эндокринология. М: Медицина; 1999: 488-95
- Ramiya V.K., Maraist M., Arfors K.E. et al. Reversal of insulindependent diabetes using islets generated in vitro from pancreatic stem cells. J. Nat. Med. 2000; 6: 278-82.
- Yamada S., Kojma I. Regenerative medicine of the pancreatic в cells. J. Hepatobiliary Pancreat. Surg. 2005; 12: 218-26.
- Gu G., Dubauskaite J., Melton D.A. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. J. Dev. 2002; 129: 2447-57.
- Плюшкина А.С., Калигин М.С., Андреева Д.И. и др. C-kit-позитивные клетки островков поджелудочной железы крысы как клетки-предшественницы эндокриноцитов при аллоксановом диабете. Клеточная трансплантология и тканевая инженерия 2012; 7(3): 138-41.
- Unger R.H., Aguilar-Parada E., Müller W.A. et al. Studies of pancreatic alpha cell function in normal and diabetic subjects. J. Clin. Invest. 1970; 49(4): 837-48.
- Kawai K., Yokota C., Ohashi S. et al. Evidence that glucagon stimulates insulin secretion through its own receptor in rats. Diabetologia 1995; 38: 274-6.
- Kawamori D., Kulkarni R. N. Insulin modulation of glucagon secretion:the role of insulin and other factors in the regulation of glucagon secretion. Islets 2009; 1: 276-9.
- Joel H. F., Stanojevic V. α-cell role in β-cell generation and regeneration Islets. Landes Bioscience 2012; 4: 188-98.
- Kilimnik G., Kim A., Steiner D. F. et al. Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of β-cell regeneration. Islets 2010; 2(3): 149-55.
- Donath Marc Y., Burcelin R. GLP-1 Effects on Islets: Hormonal, Neuronal, or Paracrine? Diabetes Care 2013; 36(2): 145-8.
- Hansen A. M. K., Bödvarsdottir T.B., Nordestgaard N.E. et al. Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus - an adaptive response to hyperglycaemia? Diabetologia 2011; 54: 1379-87.
- Holst J.J., Christensen M., Lund A. et al. Regulation of glucagon secretion by incretins. Diabetes Obes. Metab. 2011; 13(1): 89-94
- Gosmain Y., Cheyssac C., Masson M.H. et al. Pax6 is a key component of regulated glucagon secretion. Endocrinology 2012; 153(9): 4204-15.
- Gosmain Y., Marthinet E., Cheyssac C. et al. Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function. J. Biol. Chemistry 2010; 285(43): 33381-93.
- Mastracci, T.L., Wilcox, C.L., Arnes, L. et al. Nkx2. 2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev. Biol. 2011; 359: 1-11.
- Djiotsa, J., Verbruggen, V., Giacomotto, J., et al. Pax4 is not essential for beta-cell differentiation in zebrafish embryos but modulates alphacell generation by repressing arx gene expression. BMC Dev. Biol. 2012; 12-37.
- Collombat P., Mansouri A., Hecksher-Sorensen J. et al. Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes and Dev. 2003; 17(20): 2591-603.
- Collombat P., Xu X., Ravassard P. et al. The ectopic expression of Pax4 in the mouse pancreas converts progeni-.tor cells into alpha and subsequently beta-cells. Cell 2009; 138: 449-62.
- Nishimura W., Kondo T., Salameh T. et al. A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev. Biol. 2006; 293: 526-39.
- Cheng-ho Chung,Ergeng H., Piran R. et al. Pancreatic b-Cell Neogenesis by Direct Conversion from Mature a-Cells. Stem Cells 2010; 28: 1630-8.
- De Krijger R.R., Aanstoot H.J., Kranenburg G. et al. The midgestational human fetal pancreas contains cells coexpressing islet hormones J. Dev. Biol. 1992; 153: 368-75.
- Jensen J., Heller R. S., Funder-Nielsen T. et al. Independent development of pancreatic a- and ß-cells from neurogenin3-expressing precursors a role for the notch pathway in repression of premature differentiation J. Diabetes. 2000; 49: 163-76.
- Калигин М.С., Гумерова А.А, Титова М.А. и соавт. C-kit маркёр стволовых клеток эндокриноцитов поджелудочной железы. Морфология 2011; 140 (4): 32-7.
- Kordec C., Sawitza I et al. Stellate cells from rat pancreas are stem cells and can contribute to liver regeneration. PloS ONE 2012; 12: 51878.
- Калигин М.С., Плюшкина А.С., Титова А.А. и др. С-kit и десмин-позитивные клетки островков поджелудочной железы при экспериментальном диабете у крыс Клеточная трансплантология и тканевая инженерия 2013; 8 (3):113-5.
- Плюшкина А.С., Калигин М.С. Возможности использования стволовых клеток в лечении сахарного диабета Гены и клетки 2014; 9 (3): 22-4.
- Lihua Ye, Morgan A.R., Daniel Hesselson et al. Glucagon is essential for alph cell transdifferentiation and beta cell neogenesis. Dev. 2015; 142: 1407-17.
Supplementary files
