Genetic effects of medicines - lipid exchange modulators

There are medicines known as adrenoreceptors ligands, which influences a variety of lipid exchange, therefore the study of their mutagenic and antimutagenic potentials, their genotoxicity, is of great interest. The study are fullfiled using C57B4/6 mice (males) of 20 g and 1,5-2 months of age. Mutagenic and antimutagenic effects of the ligands were evaluated using in vivo tests: mouse brain skeleton cells (a number of chromosomal aberrations) and mouse peripheral red blood cells peripheral (a number of cells with micronuclei from 2000 analyzed cells). 6 male mice were used for every experimental and control variant. All medicines studied - epinephrine, phenylephrine, orciprenalin, proroxan, and propranolol (besides epinephrine, 50 mg/kg) - in a majority of doses used don't increase the level of chromosomal aberrations and the number of red blood cells with micronuclei.Epinephrin, phenylephrine, orciprenalin in doses studied demonstrated a protector effect and decreased a level of chromosomal aberrations and a number of red blood cells with micronuclei induced by cyclophosphamide administration. Proroxan and propranolol didn't change a level of aberrations. It was shown that adrenoreceptor ligands decreasing or increasing lipid level did not express mutagenic effect, and, in opposite, expressed antimutageni which testify that the system participating simultaneously in a realization of lipid exchange and mutagenesis/ antimutagenesis exists. An action of the system is realized via cell membrane receptors. According mechanism of action, the system is polyreceptoric (a- and р-adrenoreceptors take a part) and polyvalent, namely, receptor stimulators and blocators take a part in a formation of cell antimutagenesis.

mutagenesis, antimutagenesis, genotoxicity, cyclophosphamide, adrenoreceptors and their ligands