Complications, side effects and clinical application peculiarities of mobilized autologous hematopoietic stem cellsin complex therapy of patients with spinal cord injury



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Abstract

Stem cell therapy finds ever-widening application in
restoration of neural tissue, and particularly spinal cord injuries
(SCI). Still, safety problems are far from being solved and
adverse effects of the therapy remain understudied. The goal
of the study is to evaluate safety and to detect complications
and specific characteristics of clinical application of mobilized
autologous hematopoietic stem cells (AHSC) in complex
therapy of SCI. The complications have been studied at all
stages of SCI therapy: at the stage of AHSC mobilization to
peripheral blood, separation stage and cell therapy. It was
detected that overall complication rate achieved 75%. Our
study showed that AHSC therapy of SCI demands specific
training of the medical staff and must be administered in
multi-field hospital under the supervision of hematologist,
intensivist and neurologist experienced in highly technological
methods of treatment.

About the authors

S N Avdeikin,

CJSC Interventional and Restorative Neurology and Therapy Clinic «NeuroVita», Moscow

CJSC Interventional and Restorative Neurology and Therapy Clinic «NeuroVita», Moscow

A S Bryukhovetsky

CJSC Interventional and Restorative Neurology and Therapy Clinic «NeuroVita», Moscow

CJSC Interventional and Restorative Neurology and Therapy Clinic «NeuroVita», Moscow

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