Transplantation of multi-potent mesenchymal stromal cells for the treatment of graft-versus-host reaction

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About the authors

A. S. Grigoryan

Author for correspondence.
Email: redaktor@celltranspl.ru
Russian Federation

References

  1. Thomas E.D., Buckner C.D., Banaji M. et al. One hundred patients with acute leukaemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation. Blood 1977; 49: 511 -33.
  2. Appelbaum F. The current status of hematopoietic cell transplantation. Annu. Rev. Med. 2003; 54: 491-512.
  3. Aschan J. Treatment of moderate to severe acute graft-versus-host disease: a retrospective analysis. Bone Marrow Transplant. 1994; 14: 601 -7.
  4. Angeloupoulou M., Novelli E., Grove J.E. et al. Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice. Exp. Hematol. 2003; 31: 413-20.
  5. Maitra B., Szekely E., Gjini K. et al. Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation. Bone Marrow Transplant. 2004; 33: 597-604.
  6. Tse W.T., Pendleton J.D., Beyer W.M. et al. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 2003; 75: 389-97.
  7. Klyushnenkova E., Mosca J.D., Zernetkina V. et al. T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance and suppression. Biomed. Science 2005; 12: 47-57.
  8. Rasmusson I., Ringde' n O., Sundberg B. et al. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation 2003; 76: 1208.
  9. Le Blanc K., Rasmusson I., Sundberg B. et al. Treatment of severe acute graft-versus-host disease with third party haplo-identical mesenchymal stem cells. Lancet 2004; 363: 1439-41.

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