Safety and efficiency of inhalation method for administration of small extracellular vesicles derived from multipotent mesenchymal stromal cells of human umbilical cord in SARS- CoV-2 associated pneumonia
- Autores: Tiumina O.V1,2, Davydkin I.L2, Volchkov S.E1, Ovchinnikov P.A1, Bugakov A.I1, Sharonova D.U1, Konstantinov D.U2, Zolotovskaya I.A2
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Afiliações:
- Samara Regional Medical Center Dinasty
- Samara State Medical University
- Edição: Volume 17, Nº 1 (2022)
- Páginas: 19-25
- Seção: Articles
- ##submission.dateSubmitted##: 16.01.2023
- ##submission.datePublished##: 15.03.2022
- URL: https://genescells.ru/2313-1829/article/view/121889
- DOI: https://doi.org/10.23868/202205004
- ID: 121889
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Sobre autores
O. Tiumina
Samara Regional Medical Center Dinasty; Samara State Medical University
I. Davydkin
Samara State Medical University
S. Volchkov
Samara Regional Medical Center Dinasty
P. Ovchinnikov
Samara Regional Medical Center Dinasty
A. Bugakov
Samara Regional Medical Center Dinasty
D. Sharonova
Samara Regional Medical Center Dinasty
D. Konstantinov
Samara State Medical University
I. Zolotovskaya
Samara State Medical University
Bibliografia
- Akbari A., Rezaie J. Potential therapeutic application of mesenchymal stem cell-derived exosomes in SARS-CoV-2 pneumonia. Stem Cell Research & Therapy 2020; 11: 356.
- Alzahrani F., Saadeldin, I., Ahmad A. et al. The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes as Immunomodulatory Agents for COVID-19 Patients. Stem Cells International 2020; 5: 1-11.
- Yu B., Zhang X., Li X. Exosomes Derived from Mesenchymal Stem Cells. International Journal of Molecular Sciences 2014; 15(3): 4142-57.
- Rezakhani L., Kelishadrokhi A., Soleimanizadeh A. et al. Mesenchymal stem cell (MSC)-derived exosomes as a cell-free therapy for Patients Infected with COVID-19: Real Opportunities and Range of Promises. Chemistry and Physics of Lipids 2020; 234: 105009.
- Khalaj K., Figueira R., Antounians L. et al. Systematic review of extracellular vesicle-based treatments for lung injury: are EVs a potential therapy for COVID-19? Journal of Extracellular Vesicles 2020; 9(1): 1795365.
- Pinky, Gupta S., Krishnakumar V. et al. Mesenchymal Stem Cell Derived Exosomes: a Nano Platform for Therapeutics and Drg Delivery in Combating COVID-19. Stem cell reviews and reports 2021; 17(1): 33-43.
- Sengupta V., Sengupta S., Lazo A. et al. Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19. Stem cells and development 2020; 29(12): 747-54.
- Kim H., Choi D., Yun S. et al. Proteomic analysis of microvesicles derived from human mesenchymal stem cells. J. Proteome Res. 2012; 11(2): 839-49.
- Witwer K., Van Balkom B., Bruno S. et al. Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. J. Extracell. Vesicles 2019; 8(1): 1609206.
- Brave H., MacLoughlin R. State of The Art Review of Cell Therapy in the Treatment of Lung Disease, and The Potential for Aerosol Delivery. International Journal of Molecular Sciences 2020; 21: 6435.
- Волчков С.Е., Тюмина О.В. Способ получения и концентрирования микроРНК-содержащих экзосом мультипотентных мезенхимально-стромальных клеток для применения в косметических и лекарственных средствах для стимуляции регенеративных процессов и замедления процессов старения. Патент РФ на изобр. № 2710368. 26 декабря 2019.
- Jayaramayya K., Mahalaxmi I., Subramaniam M. et al. Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatment. BMB Rep. 2020; 53(8): 400-12.
- Al-Khawaga S., Essam M. Potential application of mesenchymal stem cells and their exosomes in lung injury: an emerging therapeutic option for COVID-19 patients. Stem cell research & therapy 2020; 11(1): 437-15.
Arquivos suplementares
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