Dynamics of a growth factors serum level in therapy of myocardial infarction with mesenchymalstem cells in an experiment
- Authors: Golovkin AS1, Velikanova EA1, Matveeva VG1, Saveleva EA1, Eremeev AV2, Sheina Y.I2, Svetlakov AV3
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Affiliations:
- Kemerovo Cardiology Center, Siberian branch of the RAMS
- Krasnoyarsk Center for Reproductive MedicineKrasnoyarsk State Medical InstituteInstitute of Biophysics, Siberian branch of the RAS, Krasnoyarsk
- Krasnoyarsk Center for Reproductive MedicineKrasnoyarsk State Medical Institute
- Issue: Vol 6, No 2 (2011)
- Pages: 43-47
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121658
- DOI: https://doi.org/10.23868/gc121658
- ID: 121658
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Abstract
GM-CSF concentrations in the serum of rats after postinfarct
intramyocardial injection of mesenchymal stem cells.
Myocardial infarction was simulated by the criodestruction
of the left ventricular anterior wall. Mesenchymal stem
cells were derived from rat bone marrow and injected into
myocardium 21 days after the crioinjury. The levels of TGF в,
VEGF-C and GM-CSF were measured at 3, 7 and 14 days. The
synthetic activity of the transplanted cells to these growth
factors in vitro was also measured. It was shown that the
administration of mesenchymal cells leads to an increased
level of TGF в in the peripheral blood. The maximum TGF в
concentration was observed on Day 7 after transplantation.
Despite the intensive synthesis of VEGF-C and GM-CSF by
mesenchymal cells in vitro, they do not demonstrate a
significant effect on the level of the studied growth factors in
the peripheral blood.
About the authors
A S Golovkin
Kemerovo Cardiology Center, Siberian branch of the RAMSKemerovo Cardiology Center, Siberian branch of the RAMS
E A Velikanova
Kemerovo Cardiology Center, Siberian branch of the RAMSKemerovo Cardiology Center, Siberian branch of the RAMS
V G Matveeva
Kemerovo Cardiology Center, Siberian branch of the RAMSKemerovo Cardiology Center, Siberian branch of the RAMS
E A Saveleva
Kemerovo Cardiology Center, Siberian branch of the RAMSKemerovo Cardiology Center, Siberian branch of the RAMS
A V Eremeev
Krasnoyarsk Center for Reproductive MedicineKrasnoyarsk State Medical InstituteInstitute of Biophysics, Siberian branch of the RAS, KrasnoyarskKrasnoyarsk Center for Reproductive MedicineKrasnoyarsk State Medical InstituteInstitute of Biophysics, Siberian branch of the RAS, Krasnoyarsk
Yu I Sheina
Krasnoyarsk Center for Reproductive MedicineKrasnoyarsk State Medical InstituteInstitute of Biophysics, Siberian branch of the RAS, KrasnoyarskKrasnoyarsk Center for Reproductive MedicineKrasnoyarsk State Medical InstituteInstitute of Biophysics, Siberian branch of the RAS, Krasnoyarsk
A V Svetlakov
Krasnoyarsk Center for Reproductive MedicineKrasnoyarsk State Medical InstituteKrasnoyarsk Center for Reproductive MedicineKrasnoyarsk State Medical Institute
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