Quantative effect of improving osteoinductive property of a material due to applicationof recombinant morphogenetic bone protein rhВМР-2

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Resumo

At present, novel osteoinductive materials containing
recombinant bone morphogenetic proteins (rhBMPs) are
actively being developed for «regenerative medicine»,
traumatology and orthopedics. To evaluate the effect
of rhBMPs in materials, the great interest is to study
osteoinductive properties of the materials in experimental
models in vivo. In this paper we show that application of bone
morphogenetic protein rhBMP-2 in demineralized cancellous
bone blocks provides great improving osteoinductivity of the
material in the ectopic model subcutaneous implantation in
rats. This improvement was reflected in multifold acceleration
of mineralization and in active forming a new structured
collagen matrix in the material. The model of ectopic
subcutaneous implantation to rats is very convenience test
system to detect increase in osteoinductivity of materials
caused by application of rhBMP-2, and to identify features of
ectopic bone formation in these materials.

Sobre autores

A Chekanov

1 Institute of Theoretical and Experimental Biophysics of RAS, Pushchino2 Pushchino Institute of Natural Sciences, Pushchino

1 Institute of Theoretical and Experimental Biophysics of RAS, Pushchino2 Pushchino Institute of Natural Sciences, Pushchino

I Fadeeva

1 Institute of Theoretical and Experimental Biophysics of RAS, Pushchino2 Pushchino Institute of Natural Sciences, Pushchino

1 Institute of Theoretical and Experimental Biophysics of RAS, Pushchino2 Pushchino Institute of Natural Sciences, Pushchino

V Akatov

1 Institute of Theoretical and Experimental Biophysics of RAS, Pushchino2 Pushchino Institute of Natural Sciences, Pushchino

1 Institute of Theoretical and Experimental Biophysics of RAS, Pushchino2 Pushchino Institute of Natural Sciences, Pushchino

M Solovieva

1 Institute of Theoretical and Experimental Biophysics of RAS, Pushchino2 Pushchino Institute of Natural Sciences, Pushchino

1 Institute of Theoretical and Experimental Biophysics of RAS, Pushchino2 Pushchino Institute of Natural Sciences, Pushchino

N Vezhnina

1 Institute of Theoretical and Experimental Biophysics of RAS, Pushchino2 Pushchino Institute of Natural Sciences, Pushchino

1 Institute of Theoretical and Experimental Biophysics of RAS, Pushchino2 Pushchino Institute of Natural Sciences, Pushchino

M Lekishvili

Central Institute of Traumatology and Orthopedics, Moscow

Central Institute of Traumatology and Orthopedics, Moscow

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