Development of dispersed cell system of cervical epithelium in human prenatal ontogenesis

A histological characteristic of the epithelial lining of the cervix is the most important criterion for evaluating its reactive changes. The aim of the research is to give the morphofunctional characteristics of the epithelial cells (epitheliocytes) of the cervix in human prenatal ontogenesis. 50 embryos and prefetuses from 4 to 12 weeks of fetal development, and 64 fetuses from 13 to 30 weeks of gestation have been studied Analysis was performed by using the histochemical, morphometric, cytospectrophotometric and statistical methods. Paramesonephric duct development occurs involving the coelomic epithelium, mesonephric duct epithelium and undifferentiated cells in the part of the urogenital blastema. in the late 12th and early 13th week of fetal development there is a particular area where a close interaction of the epithelial lining of the combined paramesonephric and mesonephric ducts and the dorsal wall of the urogenital area is found. The connection of the uterine channel with the external environment is formed from 13th to 20th week of development. invagination of the epithelial lining of the urogenital sinus towards the united paramesonephric ducts and the formation of a genital cord take part in this process. The junction of two kinds of epithelia: the vaginal mucosa and cervical mucosa is formed since 25th weeks of gestation. in the basal part of the cervical epithelium the individual cells are detected. According to the results of the research these cells should be classified as a derivative of the epithelial lining of the urogenital sinus. They retain their determination and due to the character of their localization may be referred to the dispersed cellular system of the mucous membrane of the cervix.

disperse cellular system of the epithelial lining of the cervix, derivatives of the epithelial lining of the urogenital sinus, embryonic histogenesis of the female genital tract