Study of the RS2910164 polymorphic variant of MIR-146A microRNA gene in patients with primary osteoporosis



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Abstract

MiRNAs, known as the family of short non-coding RNAs, are key repressors of gene expression and play an important role in the regulation of osteogenesis, interact with signaling molecules of bone remodeling, and control the processes of differentiation of bone cells. A study of the polymorphic variant rs2910164 (n. 303C>G) of the microRNA gene (miR-146a) and an assessment of its role in the formation of the risk of osteoporetic fractures and low bone mineral density (BMD) in a sample of postmenopausal women and men over 45 years of age was conducted. The C allele was found to be associated with a low level of bone mineral density in the lumbar spine in women. There were no significant associations of the studied locus with osteoporotic fractures in General and their separate localities in men and women, with a low level of BMD in General and various localities in men.

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About the authors

B. I Yalaev

Institute of Biochemistry and Genetics - subdivision of the Ufa Federal Research Centre of the RAS

Email: yalaev.bulat@yandex.ru

R. I Khusainova

Institute of Biochemistry and Genetics - subdivision of the Ufa Federal Research Centre of the RAS

Email: ritakh@mail.ru

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