Regulation development of bone marrow postnatal stem cells by specific xenogenic immune globulins
- Авторлар: Selivanov, EA1, Rugal VI1
-
Мекемелер:
- Russian Research Institute of Hematology and Transfusiology, Saint-Petersburg
- Шығарылым: Том 6, № 4 (2011)
- Беттер: 34-38
- Бөлім: Articles
- ##submission.dateSubmitted##: 11.01.2023
- ##submission.datePublished##: 15.12.2011
- URL: https://genescells.ru/2313-1829/article/view/121667
- DOI: https://doi.org/10.23868/gc121667
- ID: 121667
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Рұқсат ақылы немесе тек жазылушылар үшін
Аннотация
The regulation development of haemopoietic stem cells by
rabbit anti-human CD34+ stem cells immune globulin has been
established. It was showed by experimental investigation on
rats with cytostatic haemo-immunosuppression and in culture
human CD34+ stem cells. Thus, in animals which received
anti-CD34+ immune globulin the recovery of blood and
immunity values occurred earlier than in the control animals.
The experimental animals recovered haemolymphocytopoiesis
after one month while control group normalized haemopoietic
function after two months. In vitro colony-forming ability
human haemopoietic stem cells are increased in 30 per cent
by the addition specific CD34+ immune globulin in counditioned
medium. Our preliminary date suggest that rabbit anti-human
mesenchymal stem cells immune globulin can stimulate the
differentiation of mesenchymal cells in osteoblasts and
endotheliocytis the cells that form haemopoietic niche.
rabbit anti-human CD34+ stem cells immune globulin has been
established. It was showed by experimental investigation on
rats with cytostatic haemo-immunosuppression and in culture
human CD34+ stem cells. Thus, in animals which received
anti-CD34+ immune globulin the recovery of blood and
immunity values occurred earlier than in the control animals.
The experimental animals recovered haemolymphocytopoiesis
after one month while control group normalized haemopoietic
function after two months. In vitro colony-forming ability
human haemopoietic stem cells are increased in 30 per cent
by the addition specific CD34+ immune globulin in counditioned
medium. Our preliminary date suggest that rabbit anti-human
mesenchymal stem cells immune globulin can stimulate the
differentiation of mesenchymal cells in osteoblasts and
endotheliocytis the cells that form haemopoietic niche.
Авторлар туралы
E Selivanov,
Russian Research Institute of Hematology and Transfusiology, Saint-PetersburgRussian Research Institute of Hematology and Transfusiology, Saint-Petersburg
V Rugal
Russian Research Institute of Hematology and Transfusiology, Saint-PetersburgRussian Research Institute of Hematology and Transfusiology, Saint-Petersburg
Әдебиет тізімі
- Lim P., Tow A. Recovery and Regeneration after Spinal Cord in jury. Ann. Acad. Med. Sinkapure 2007; 36: 49-57.
- Thomas E.D. Bone marrow transplantation from a personal viewpoint. Int. J. Hematol. 2005; 23: 463-70.
- Anversa P. Cardiac regeneration. J. Am. Coll. Cardiol. 2006; 47(9): 1769-76.
- Charwat S., Gyongyo M., Lana I. et al. Role of adult bone marrow stem cell in the repair of ischemic myocardium. Exp. Hematol. 2008; 36: 672-80.
- Yao K., Huang R., Qian J. et al. Administration of intracoronary bone marrow mononuclear cells in chronic myocardial infarction improves diastolic function. Heart 2008; 94: 1147-53.
- Baron F., Moris M., Sandmaier B. et al. Graft-versus-tumor effects after allogenic hematopoietic cell transplantation with nonmyeloablative conditioning. J. Clin. Oncol. 2005; 23(9): 1993- 2003.
- Carnevale-Shianca F., Ricchiardi A., Capaldi A. et al. Allogenic haemopoietic stem cells transplantation in solid tumors. Transplant. Proc. 2005; 37(6): 2664-6.
- Metz I., Lukinetti C.F., Openshaw H. Autologous haemopoietic stem cells transplantation fails to stop demyelination and neurodegeneration in multiple sclerosis. Brain 2007; 130(5): 1254-62.
- Lim P., Tow A. Recovery and Regeneration after Spinal Cord in jury. Ann. Acad. Med. Sinkapure 2007; 36: 49-57.
- Masson S., Harrison D.J., Pervis J.N. Potential of haemopoietic stem cells therapy in hepatology: critical review. Stem cells 2004; 22(6): 897-90.
- Гончар В.А., Абдулкадыров К.М., Ругаль В.И. и др. Средство для активации стволовых клеток. Патент Российской федерации № 227810. 26.03.2006.
- Романенко Н.А. Заготовка и хранение ядросодержащих клеток пуповинной крови человека. Автореф. дисс. кандидата мед. наук. Санкт-Петербург; 2002.
- Askmyr M., Sims N.A., Martin T.J. et al. What is the nature of the osteoblastic haemopoietic stem cell niche? Trends in Endocrin. Metabol. 2009; 20(6): 303-09.
- Papayannopoulou T., Scadden D. Stem-cell ecology and stem cells in motion. Blood 2008; 111: 3923-30.
- Zhang J., Nin C., Ye L. et al. Identification of the haemopoietic stem cell niche and control of the niche size. Nature 2003; 425: 836-41.
- Барановский Ф.Ю., Каныкин А.Ю. Мазуркевич Е.А. и др. Мезенхимальные стволовые клетки при травме кости. Материа- лы 8 национального конгресса «Человек и его здоровье». Санкт- Петербург; 2003.
- Gonchar V.A., Rugal V.I. The new preparation as stimulator of calcified tissue regeneration. Calc. Tissue 2000; 66: 91.
- Зорин В.Л., Черкасов В.Р., Зорина В.И. и др. Характеристи- ка мирового рынка клеточных технологий. Клеточная транспланто- логия и тканевая инженерия 2010; 5(3): 96-115.
Қосымша файлдар
