Nanocomposite material for stomatology restovration particles cytotoxicity: an in vitro study

Nanocomposite material applied in dental practice treatment is subjected to mechanical abrasion with the release of material’s fine particles, including nanoparticles, which are able to produce a specific biological effect on patient body’s tissues and cells. I the present research we studied the cytotoxicity of 3MTMESPETMFiltekTMUltimate nanocomposite particles at concentration ranging from 10 to 0. 009 mg/ml employing human lung carcinoma cell culture (A549). Linear dependence of nanocomposite particles’ action on survival and functional activity of the cells was shown. The crucial concentration of cytotoxicity should be considered as 0. 313 mg/ml. At 0.156 mg/ml or below this concentration the tested substance had no toxic effect on A549 cells Considering the possible negative effect of nanocomposite particles released during the material abrasion on cells we suggest limiting application of the studied nanocomposite material on the surfaces subjected to intensive mechanical impact leading to high abrasion

3MESPEFiltekUltimate nanocomposite, cytotoxicity, A549 human lung carcinoma cells