Pten gene is a new target for selective suppression of leukemia stem cells

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About the authors

V. S. Melikhova

Author for correspondence.
Email: redaktor@celltranspl.ru
Russian Federation

References

  1. Reya T., Morrison S.J., Clarke M.F., Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature 2001 ; 414: 105-11.
  2. Bonnet D., Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997; 3: 730-7.
  3. Rossi D.J., Bryder D., Zahn J.M. et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc. Natl. Acad. Sci. USA 2005; 102(26): 9194-9.
  4. Rossi D.J., Weissman I.L. Pten, tumorigenesis and stem cell self-renewal. Cell 2006; 125(2): 229-31.
  5. Caussinus E., Gonzalez C. Induction of tumor growth by altered stem cell asymmetric division in Drosophila melanogaster. Nat. Genet. 2005; 37(10): 1125-9.
  6. Stiles B., Groszer M., Wang S. et al. PTENless means more. Dev. Biol. 2004; 273: 175-84.
  7. Cully M., You H., Levine A.J., Mak T.W. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nature Rev. Cancer 2006; 6: 184-92.
  8. van Rhenen A., Feller1 N., Kelder A. et al. The novel AML stem cell associated antigen CLL-1 discriminates between normal and leukemic stem cells. Blood (ASH Annual Meeting Abstracts) 2005; 106: Abstract 4.

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