ANALYSIS OF HIPPOCAMPAL CA1 NEURONS DENDRITIC SPINES PATHOMORPHOLOGICAL CHANGES IN THE 5XFAD-M MOUSE MODEL OF ALZHEIMER'S DISEASE



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About the authors

A. R Ilina

Saint Petersburg Institute of Bioregulation and Gerontology; Peter the Great Saint-Petersburg Polytechnic University

Email: juin96@mail.ru
Saint Petersburg, Russia

N. A Kraskovskaya

Peter the Great Saint-Petersburg Polytechnic University

Saint Petersburg, Russia

N. S Linkova

Saint Petersburg Institute of Bioregulation and Gerontology; Academy of postgraduate education under FSBU FSCC of FMBA of Russia

Saint Petersburg, Russia

References

  1. Bourne J.N., Harris K.M. Balancing structure and function at hippocampal dendritic spines. Annu. Rev. Neurosci 2008; 31: 47-67.
  2. Feng G., Mellor R. H., Bernstein M., et al. Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP. Neuron 2000; 28(1): 41-51.
  3. Oakley H., Cole S.L., Logan S., et al. Intraneuronal p-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation. J Neurosci 2006; 26(40): 10129-40.
  4. Smith C.A., Chauhan B.C. In vivo imaging of adeno-associat-ed viral vector labelled retinal ganglion cells. Sci Rep 2018; 8(1).
  5. Terry R.D., Masliah E., Salmon D.P., et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991; 30(4): 572-80.

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