HIGH CONTENT SCREENING OF POTENTIAL DRUG COMPOUNDS TO DETECT MODULATORY EFFECTS ON CYTOCHROME P450 (CYP) ENZYMES

Authors: Klyushova L.S¹
Affiliations:
1. Institute of Molecular Biology and Biophysics - subdivision of FRC FTM
Issue: Vol 15, No 3S (2020)
Pages: 51-52
Section: Articles
URL: https://genescells.ru/2313-1829/article/view/122639
DOI: https://doi.org/10.23868/gc122639
ID: 122639

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Institute of Molecular Biology and Biophysics - subdivision of FRC FTM

Email: klyushovals@mail.ru
Novosibirsk, Russie

Zanger U.M., Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. PharmacolTher. 2013; 138 (1): 103-141.
Lolodi O.et al. Differential Regulation of CYP3A4 and CY-P3A5 and Its Implication in Drug Discovery. Curr Drug Metab. 2017; 18(12): 1095-1105.
Eremina J. A.et al. Mixed-ligand copper(ll) complexes with tetrazole derivatives and 2,2'-bipyridine, 1,10-phenanthroline: synthesis, structure and cytotoxic activity. Inorg. Chim. Acta. 2019; 487: 138-144.
Mattiazzi U.M.et al. High-Content Screening for Quantitative Cell Biology. Trends Cell Biol. 2016; 26(8): 598-611.

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