Reserve and basal cells of epithelia of cervix uteri as a source of cervical neoplasies by human papilloma viruses



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Abstract

As progenitor of cervical epithelium consider reserve and basal cells. They as human stem cells possess ability of self-updating, manufacture of the differentiated functional posterity and settle down in a niche. They supports the population by means of mitosis. For a reserve cell it is characteristic expression p63, bcl-2, keratins 5, 7, 17, for basal cells - p63, bcl-2, keratins 5, 7, 10, 13, 14, 17. Reserve cells are a source of development of columnar and squamous epithelia of cervix uteri, basal cells - only squamous epithelium. Reserve and basal cells are cells-targets for human papilloma virus (HPV) which genetic changes can serve as the reason can-cerogenesis. For "precancerous” cervical intraepithelial neoplasies in prevailing number of supervision spontaneous regress is characteristic. The role of integration of DNA HPV in cancerogenesis of cervix uteri does not find unequivocal acknowledgement in DNA of a cell. Modern representations about cancer stem cell of cervix uteri characterize its similarity to stem cells of cervical epithelium.

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About the authors

V. A Ershov

Municipal Clinical Oncology Dispensary

Email: ershov@gkod.spb.ru
Saint Petersburg, Russia

V. M Mikhailov

Institute of Cytology Russian Academy of Science

Saint Petersburg, Russia

V. S Chirsky

S.M. Kirov Military Medical Academy

Saint Petersburg, Russia

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